Source of Support: None, Conflict of Interest: None
Fever is a very common problem in neurological intensive care units (NICU) and in about a half the patients fever is associated with and infections. There is overwhelming evidence from both experimental and clinical studies to suggest that elevated temperature has deleterious effects on the acutely injured brain and is associated with poor outcome. There are no data on the effect of elevated temperature on the injured brain in patients with infections of central nervous system. Elevated temperature irrespective of the etiology should be treated aggressively. Antipyretic drugs lower body temperature in pyrogen-induced fever, which implies intact thermoregulation, but may be ineffective in brain-injured patients with impaired thermoregulatory mechanisms. It appears that cooling devices both external and endovascular, are promising in the treatment of fever in NICU.