Annals of Indian Academy of Neurology
  Users Online: 910 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
Year : 2004  |  Volume : 7  |  Issue : 2  |  Page : 357-367

Homocysteine And Stroke



Correspondence Address:
D Nagaraja


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

In recent years, a great deal of attentions has been focused on the role of homocysteine, a sulfur-containing amino acid, in the etiopathogenesis of atherothromobtic vascular disease. Multiple prospective and case-control studies have shown that a moderately elevated plasma homocysteine concentration is an independent risk factor for stroke. The exact molecular mechanism by which homocysteine or related metabolites promote atherothrombosis is unknown although several possible roles have been proposed. It is generally held that homocysteine promotes thrombosis by adversely affecting the functions of the vascular endothelium that maintain the blood's fluidity. Homocysteine concentrations are determined by genetic and nutritional factors including deficiencies of folate, vitaminB12 and B5 supplementation with the nutrient cofactors required for optimal functioning of the homocysteine metabolic pathways significantly impacts homocysteine levels, and offers a new integrated possibility for prevention of first and recurrent episodes stroke.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed841    
    Printed60    
    Emailed2    
    PDF Downloaded134    
    Comments [Add]    

Recommend this journal