Annals of Indian Academy of Neurology
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REVIEW ARTICLE
Year : 2006  |  Volume : 9  |  Issue : 4  |  Page : 199-206

Steroids in childhood epilepsy


Division of Paediatric Neurology, McMaster Children’s Hospital, McMaster University, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5

Correspondence Address:
Rajesh Ramachandrannair
Division of Pediatric Neurology, Michael G. DeGroote School of Medicine, McMaster University, McMaster Children’s Hospital, HSC 3N 11, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.29201

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Treatment of epileptic encephalopathies can be very challenging as most anticonvulsant drugs fail to achieve good seizure control. Steroids are disease modifying as well as anticonvulsant in these conditions. Though steroids are accepted as the first-line treatment for infantile spasms, there are many unanswered questions with regard to the preparation, dose and duration of treatment. In this review a re-exploration of the literature is attempted. Putative mechanism of action of steroids in infantile spasms is also discussed. As steroids are being increasingly used in other epileptic encephalopathies and Rasmussen's encephalitis, a brief discussion on the role of steroids in these conditions is attempted. The review ends with the discussion on newer neuroactive steroids in the management of epilepsy.


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