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Annals of Indian Academy of Neurology
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REVIEW ARTICLE
Year : 2007  |  Volume : 10  |  Issue : 3  |  Page : 137-144

Acute disseminated encephalomyelitis


Associate Professor in Neurology, In-charge Rehabilitation Centre, Amrita Institute of Medical Sciences, Kochi - 682 026, India

Correspondence Address:
J N Panicker
Associate Professor in Neurology, In-charge Rehabilitation Centre, Amrita Institute of Medical Sciences, Kochi - 682 026
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.34792

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Acute disseminated encephalomyelitis (ADEM) presents as an acute-onset neurological dysfunction following a triggering event such as an infection or vaccination. Patients present with polysymptomatic neurological dysfunction, and imaging shows multifocal white matter lesions in the brain and spinal cord. Clinical evaluation, magnetic resonance imaging, and cerebrospinal fluid study are most useful in establishing the diagnosis and ruling out important differential diagnoses. Corticosteroids are the mainstay of treatment and the role of other modalities of treatment, such as plasma exchange and intravenous immunoglobulin, require further study. Prognosis is generally good. The recently proposed consensus definitions are likely to facilitate delineation of ADEM from other acquired demyelinating disorders.


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