Annals of Indian Academy of Neurology
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THE BALDEV SINGH ORATION
Year : 2008  |  Volume : 11  |  Issue : 3  |  Page : 140-145

Autoantibodies in neuromuscular transmission disorders


Department of Clinical Neurology and Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom

Correspondence Address:
Angela Vincent
Department of Clinical Neurology, West Wing, John Radcliffe Hospital, Oxford OX3 9DU
United Kingdom
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DOI: 10.4103/0972-2327.42932

PMID: 19893659

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It is a great pleasure to be asked to honour the memory of Dr. Baldev Singh by reviewing the field of autoantibodies in myasthenia gravis and other neurotransmission disorders. The neuromuscular junction (NMJ) is the site of a number of different autoimmune and genetic disorders, and it is also the target of many neurotoxins from venomous snakes, spiders, scorpions and other species. The molecular organization of the NMJ is graphically represented in [Figure 1A], where different ion channels, receptors and other proteins are shown. Four of the ion channels or receptors are directly involved in autoimmune diseases. This brief review will not only concentrate on these conditions but also illustrate how their study is helping us to understand the etiology of rare but treatable neurological syndromes of the central nervous system.


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