Annals of Indian Academy of Neurology
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REVIEW ARTICLE
Year : 2009  |  Volume : 12  |  Issue : 1  |  Page : 3-11

Application of mass spectrometry-based proteomics for biomarker discovery in neurological disorders


1 Institute of Bioinformatics, Bangalore 560 066,India
2 Institute of Bioinformatics, Bangalore 560 066,India; McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA
3 McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA

Correspondence Address:
Akhilesh Pandey
527 Broadway Research Building, 733 N. Broadway, Baltimore, MD 21205, USA

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.48845

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Mass spectrometry-based quantitative proteomics has emerged as a powerful approach that has the potential to accelerate biomarker discovery, both for diagnostic as well as therapeutic purposes. Proteomics has traditionally been synonymous with 2D gels but is increasingly shifting to the use of gel-free systems and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Quantitative proteomic approaches have already been applied to investigate various neurological disorders, especially in the context of identifying biomarkers from cerebrospinal fluid and serum. This review highlights the scope of different applications of quantitative proteomics in understanding neurological disorders with special emphasis on biomarker discovery.


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