Annals of Indian Academy of Neurology
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ORIGINAL ARTICLE
Year : 2010  |  Volume : 13  |  Issue : 1  |  Page : 33-36

Assessment of serum L-fucose in brain tumor cases


1 Department of Biochemistry, Yenepoya Medical College, Mangalore, India
2 Department of Biochemistry, Mandya Institute of Medical Sciences, Mandya, Karnataka, India
3 Department of Medical Pharmacology & Physiology, University of Missouri School of Medicine, Columbia MO 65212, Colombia
4 Department of Neurology, Kasturba Medical College, Manipal, Karnataka, India
5 Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka, India

Correspondence Address:
S Manjula
Department of Biochemistry, Yenepoya Medical College, Mangalore- 575 018, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.61274

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Background: Glycosylation of altered tumor cell in relation to cellular heterogeneity in human intracranial tumors remains relatively unexposed. Serum protein-bound carbohydrate, L-Fucose is reported to be overexpressed during tumor progression by many investigators. Therefore, there is a need to determine the diagnostic, prognostic, functional significance of glycoprotein elevations in various cases of tumors. Objective: The objective of the present study was to evaluate the clinical utility of serum L-fucose in patients with brain tumor. Materials and Methods: Serum glyco-conjugate levels were estimated in 99 patients with brain tumors. Estimation of L-fucose was carried out colorimetrically by the method of Winzler using cysteine hydrochloride. Results: There was a significant increase in L-fucose level in most of the patients. In the posttreatment cases, the L-fucose levels were apparently low compared to preoperative values. Conclusion: Our results showed that the rise in serum L-fucose may be used as a general marker for brain tumors in addition to other markers.


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