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Annals of Indian Academy of Neurology
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CASE REPORT
Year : 2010  |  Volume : 13  |  Issue : 3  |  Page : 207-210

Dramatic response to infliximab in refractory neurosarcoidosis


1 Department of Rheumatology, Stony Brook University Medical Center, Stony Brook, NY, USA
2 Rheumatic Disease Clinic of Houston, Houston, TX, USA

Correspondence Address:
Sreekanth Chintamaneni
SUNY Stony Brook HSC, Level 16 RM 040, Stony Brook, NY 11794
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.70874

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Sarcoidosis is a systemic disease characterized by noncaseating granulomas in the involved organs. Neurologic manifestations involving the central and/or peripheral nervous system occur in about 5% of patients. Neurosarcoidosis is often refractory to conventional treatment and therefore more effective treatment options are needed. While the etiology of the disease is still unknown, there is now a better understanding of its pathogenesis on a molecular level. It is clear that tumor necrosis factor-α (TNFα) plays a pivotal role in the development of the granulomas and it is believed to be a key cytokine involved in the pathogenesis of the disease. Taking advantage of this better understanding of disease pathogenesis, anti-TNFα agents are being increasingly used to treat refractory sarcoidosis. We report a patient with refractory neurosarcoidosis who showed dramatic improvement in the clinical and radiological manifestations following treatment with infliximab; he suffered a relapse upon discontinuation of the medication.


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