Annals of Indian Academy of Neurology
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REVIEW
Year : 2010  |  Volume : 13  |  Issue : 6  |  Page : 89-93

Cellular basis of Alzheimer's disease


Systems and Cell Biology of Neurodegeneration, Psychiatry Research, University of Zürich, 8008 Zurich, Switzerland

Correspondence Address:
Lawrence Rajendran
Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, August-Forel Str. 1, 8008 Zurich
Switzerland
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.74251

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Alzheimer's disease (AD) is the most common form of neurodegenerative disease. A characteristic feature of the disease is the presence of amyloid-β (Aβ) which either in its soluble oligomeric form or in the plaque-associated form is causally linked to neurodegeneration. Aβ peptide is liberated from the membrane-spanning -amyloid precursor protein by sequential proteolytic processing employing β- and γ-secretases. All these proteins involved in the production of Aβ peptide are membrane associated and hence, membrane trafficking and cellular compartmentalization play important roles. In this review, we summarize the key cellular events that lead to the progression of AD.


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