Annals of Indian Academy of Neurology
  Users Online: 7601 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
CASE REPORT
Year : 2011  |  Volume : 14  |  Issue : 4  |  Page : 316-318

Coexistence of primary sclerosing cholangitis in a patient with myasthenia gravis


1 Neurology Division, Department of Internal Medicine, Federal University of Paraná, Curitiba PR, Brazil
2 Gastroenterology Division, Department of Internal Medicine, Federal University of Paraná, Curitiba PR, Brazil

Correspondence Address:
R H Scola
Serviço de Neurologia, Hospital de Clínicas da UFPR, Rua General Carneiro 181/3o andar, 80060-900 Curitiba PR
Brazil
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.91966

Rights and Permissions

Myasthenia gravis (MG) is an immune-mediated disease that compromises the postsynaptic membrane of the neuromuscular junction. Primary sclerosing cholangitis (PSC) is considered an immune-mediated cholestatic liver disease. Both MG and PSC include an autoimmune pathogenesis, so there is some evidence that patients with MG or PSC have a higher risk of developing autoantibodies and other immune disorders than normal controls, but the coexistence of these two disorders has never been documented. We report a 40-year-old woman who presented with MG when she was 20 years old and developed PSC 20 years after a thymectomy. Liver biochemistry revealed cholestasis. Magnetic resonance imaging showed multifocal strictures and beads involving the intrahepatic bile ducts. A liver biopsy confirmed sclerosing cholangitis. Serological analysis demonstrated positive autoantibodies (Anti-nuclear antibodies, anti-smooth muscle antibodies). Repetitive stimulation had a decremental response, and antibodies to acetylcholine receptors were detectable. To our knowledge, this is the first case of PSC in a patient with MG. The main characteristics of both MG and PSC combination are discussed.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2071    
    Printed74    
    Emailed0    
    PDF Downloaded36    
    Comments [Add]    
    Cited by others 1    

Recommend this journal