Annals of Indian Academy of Neurology
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Table of Contents
LETTER TO THE EDITOR
Year : 2012  |  Volume : 15  |  Issue : 3  |  Page : 230-231
 

Authors' reply


1 Department of Neurology, Malabar Institute of Medical Sciences, Calicut, Kerala, India
2 Department of Medicine, Malabar Institute of Medical Sciences, Calicut, Kerala, India

Date of Web Publication14-Aug-2012

Correspondence Address:
V V Ashraf
Department of Neurology, Malabar Institute of Medical Sciences, Govindapuram PO, Calicut- 673 016, Kerala
India
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Source of Support: None, Conflict of Interest: None


PMID: 22919204

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How to cite this article:
Ashraf V V, Chaudhary NV, Kumar R P, Gopalakrishnan B, Girija A S. Authors' reply. Ann Indian Acad Neurol 2012;15:230-1

How to cite this URL:
Ashraf V V, Chaudhary NV, Kumar R P, Gopalakrishnan B, Girija A S. Authors' reply. Ann Indian Acad Neurol [serial online] 2012 [cited 2019 Oct 14];15:230-1. Available from: http://www.annalsofian.org/text.asp?2012/15/3/230/99734


Sir,

We agree with the authors that, the risk (low cholesterol) was not identified before the event (intra-cerebral hemorrhage) onset in our study. Potential source of error in our study is the use of lipid values within 48 hours of the ICH as estimates of the pre-hemorrhage levels. We had already admitted this limitation in our paper. Segal AZ et al, [1] in a better study design, taking serum cholesterol level at 3 months after ICH as an estimate of pre ICH cholesterol level also found the inverse association between low cholesterol and risk of ICH. The association of pre ICH cholesterol level and risk of ICH was studied by K Yano et al, [2] as a part of Honolulu heart program and inverse association between serum cholesterol and risk of ICH was found. We agree that proper assessment of risks and benefits of low cholesterol level will only be established by a large cohort study.

 
   References Top

1.Segal AZ, Chiu RI, Egglesten-Sexton PM, Beiser A, Greenberg SM. Low cholesterol as a risk factor for primary intra-cerebral hemorrhage: A case control study. Neuroepidemiology 1999;18:185-93.  Back to cited text no. 1
    
2.Yano K, Reed DM, Maclean CJ. Serum cholesterol and hemorrhagic stroke in Honolulu Heart Program. Stroke 1989;20:1460-5.  Back to cited text no. 2
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