Annals of Indian Academy of Neurology
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REVIEW
Year : 2013  |  Volume : 16  |  Issue : 3  |  Page : 310-318

Mild cognitive impairment in adult: A neuropsychological review


1 Hainan People's Hospital, First Aid Center EICU, Hainan, China
2 Department of Psychiatry, Postgraduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, India
3 Department of Physiology, M. S. Ramaiah Medical College, Bangalore, Karnataka, India

Correspondence Address:
Mina Chandra
IA 67B, DDA Flats, Ashok Vihar Phase 1, Delhi - 110 052
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.116907

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Mild cognitive impairment (MCI) is associated with an increased risk of developing dementia. This is clinically relevant as overt dementia can be prevented if treatment strategies are devised for MCI. Neuropsychological deficits in this condition are very common and are important clinically for treatment and outcomes. We aimed to review various neuropsychological deficits in MCI. Further, we have presented the current evidence for nosological status, neuroanatomical basis, and clinical outcome of this heterogeneous construct. All published papers on the topic of neuropsychological deficits in MCI on Medline and other databases were reviewed. A wide range of memory and executive function deficits are common in MCI patients. However, several studies are limited by either improper designs or inadequate sample sizes. Several neuropsychological impairments like memory function and executive functions can be diagnosed in MCI. The evidence base for the exact neuroanatomical basis of MCI is not robust yet. However, given the wide range of outcomes, controversies and debates exist regarding the nosological significance of the deficits. Hence, more studies are needed to specifically localise the impairments and further delineate the construct of MCI.


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