Annals of Indian Academy of Neurology
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ORIGINAL ARTICLE
Year : 2013  |  Volume : 16  |  Issue : 3  |  Page : 380-383

Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients


1 Department of Professional Medicine, Neurosurgery Division, Kaohsiung Armed Forces General Hospital, VAC, EY, Taiwan
2 Rehabilitation Division, Kaohsiung Veterans General Hospital, VAC, EY, Taiwan
3 Asia Pacific Biotech Developing, Inc, Kaohsiung, Taiwan
4 Department of Biotechnology, Yung Ta Institute of Technology & Commerce, Pingtung, Taiwan

Correspondence Address:
Wen-Sheng Liu
Department of Biotechnology, Yung Ta Institute of Technology & Commerce, 316 Chung Shan Road Lin Ti Tsun Lin Lo Pingtung, 909
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.116950

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Background: Ischemic stroke (IS) is a prevalent disease causing a body disability, the third leading cause of death in Taiwan. It shows that the level of intercellular adhesion molecular-1 (ICAM-1) in IS patients is higher than control subjects. Objective: This study is to investigate the possible association of ICAM-1 (G1548A) polymorphism in IS patients. Materials and Methods: A total of 646 subjects were enrolled in this study, including 312 IS patients, and 334 controls without a history of symptomatic IS. The ICAM-1 (G1548A) polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism. Clinical factors were also determined. Results: The frequencies of the ICAM-1 (G1548A) polymorphism for G/G, G/A, and A/A were 74.8%, 23.9%, and 0.3%, respectively, in healthy controls, and 62.8%, 32.1%, and 5.1%, respectively, in patients. The frequency of the ICAM-1 (G1548A) A allele (21.2% versus 13.2%, respectively; P = 0.007) and the carriers of the ICAM-1 (G1548A) A allele (37.2% versus 25.2%; P = 0.019, OR 1.76, 95% CI 1.1-2.83) are great in IS patients compared with healthy controls. There is a higher risk of IS associated with homozygosity for the ICAM-1 (G1548A) A allele (AA genotype) compared with the control population (5.1% vs. 0.3%, respectively, P = 0.04; OR 5.1, 95% CI 1.19-21.66). We also observed both hypertension and diabetes has shown a positive association with IS. Conclusions: The ICAM-1 (G1548A) polymorphism was associated with independent risk factor for the development of IS.


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