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Table of Contents
LETTER TO THE EDITOR
Year : 2013  |  Volume : 16  |  Issue : 3  |  Page : 462
 

Serum iron may not be linked with migraine


1 Department of Psychiatry; Sleep Clinic, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, India
2 Department of Psychiatry, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, India
3 Department of Neurology; Sleep Clinic, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, India

Date of Web Publication26-Aug-2013

Correspondence Address:
Ravi Gupta
Department of Psychiatry and Sleep Clinic, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun 248 140
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.116959

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How to cite this article:
Gupta R, Lahan V, Goel D. Serum iron may not be linked with migraine. Ann Indian Acad Neurol 2013;16:462

How to cite this URL:
Gupta R, Lahan V, Goel D. Serum iron may not be linked with migraine. Ann Indian Acad Neurol [serial online] 2013 [cited 2019 Aug 23];16:462. Available from: http://www.annalsofian.org/text.asp?2013/16/3/462/116959


Sir,

'We are thankful to the authors for their interest in this manuscript. [1] We agree with the fact that exclusion of subjects with iron deficiency would have improved the quality of our study. To support it, they have cited a study that shows that iron deficiency might be related to menstrual migraine. [2] We did not consider exclusion of iron-deficient subjects owing to a number of facts: First, this was not the aim of the study; second, considering a high prevalence of iron deficiency in India, this was not practical; lastly, iron deficiency has been reported in a number of Restless Legs Syndrome patients.

As far as the relationship between iron and migraine is considered, this could be an over-simplistic explanation for this complex issue. The cited article had enrolled subjects with migraine whereas inclusion criterion in the present study was RLS. [2] Hence, both the studies cannot be compared directly. In addition, that study had found a relationship between menstrual migraine and iron deficiency but not between migraine and iron deficiency. [2] Thus, this finding cannot be generalized to all migraineurs. Moreover, a study that enrolled the RLS patients, like our study, did not find any effect of serum iron on the migraine. [3] To make the issue more complex, a number of studies have reported increased iron depiction in deep brain nuclei among migraineurs. [4],[5] On the other hand, iron has been found to be decreased in the central nervous system of RLS patients. [6],[7]

In conclusion, more work is required to understand this complex issue.


   Acknowledgment Top


We are thankful to MAPI Research Trust and Dr. Charles Morin for providing us the consent to use international restless leg syndrome severity rating scale (IRLS) Hindi version and insomnia severity index Hindi version in this study, respectively.

 
   References Top

1.Gupta R, Lahan V, Goel D. Primary headaches in restless legs syndrome patients. Ann Indian Acad Neurol 2012;15:S104-8.  Back to cited text no. 1
    
2.Vukoviæ-Cvetkoviæ V, Plavec D, Lovrenciæ-Huzjan A, Galinoviæ I, Seriæ V, Demarin V. Is iron deficiency anemia related to menstrual migraine? Post hoc analysis of an observational study evaluating clinical characteristics of patients with menstrual migraine. Acta Clin Croat 2010;49:389-94.  Back to cited text no. 2
    
3.Suzuki S, Suzuki K, Miyamoto M, Miyamoto T, Watanabe Y, Takashima R, et al. Evaluation of contributing factors to restless legs syndrome in migraine patients. J Neurol 2011;258:2026-35.  Back to cited text no. 3
    
4.Kruit MC, van Buchem MA, Launer LJ, Terwindt GM, Ferrari MD. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: The population-based MRI CAMERA study. Cephalalgia 2010;30:129-36.  Back to cited text no. 4
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5.Kruit MC, Launer LJ, Overbosch J, van Buchem MA, Ferrari MD. Iron accumulation in deep brain nuclei in migraine: A population-based magnetic resonance imaging study. Cephalalgia 2009;29:351-9.  Back to cited text no. 5
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6.Pedroso JL, Bor-Seng-Shu E, Felicio AC, Braga-Neto P, Dutra LA, de Aquino CC, et al. Severity of restless legs syndrome is inversely correlated with echogenicity of the substantia nigra in different neurodegenerative movement disorders. A preliminary observation. J Neurol Sci 2012;319:59-62.  Back to cited text no. 6
    
7.Connor JR, Ponnuru P, Wang XS, Patton SM, Allen RP, Earley CJ. Profile of altered brain iron acquisition in restless legs syndrome. Brain 2011;134:959-68.  Back to cited text no. 7
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