|Year : 2014 | Volume
| Issue : 1 | Page : 25-29
A retrospective study of toddlers with autism spectrum disorder: Clinical and developmental profile
Prahbhjot Malhi, Pratibha Singhi
Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India
|Date of Submission||15-Jun-2013|
|Date of Decision||29-Jul-2013|
|Date of Acceptance||25-Sep-2013|
|Date of Web Publication||12-Mar-2014|
Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh - 160 012
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Objective: To retrospectively examine the developmental and clinical characteristics of children with autism spectrum disorders (ASD) in the first 2 years of life in order to narrow the interval between parental concern and getting a reliable diagnosis of autism. Materials and Methods: The case records of 21 children in whom a diagnosis of ASD was made in the first 2 years of life and confirmed 6 months to 1 year later were examined. The inclusion criterion was absence of neurological, metabolic, or genetic disorders and sensory or motor impairments. These case records were maintained in the Pediatric Psychology Clinic at the Department of Pediatrics of a tertiary care teaching hospital in North India. Results: The average age at presentation to the clinic was 21.23 months (SD = 2.18). The clinical characteristics that were found in two-thirds or more children included lack of speech, inability to follow verbal commands, lack of pretend play, no index finger pointing, difficulty in playing with toys in a constructive manner, lack of joint attention, and motor stereotypies. The mean IQ was 66.62 (SD = 15.11) and the mean SQ as measured by the Vineland Social Maturity Scale was 80.43 (SD = 17.45). Conclusions: Given the validity of early diagnosis over time, clinicians should be encouraged not only to make an early diagnosis but also to initiate early interventions in children with ASD.
Keywords: Autism spectrum disorders, development, India, toddlers
|How to cite this article:|
Malhi P, Singhi P. A retrospective study of toddlers with autism spectrum disorder: Clinical and developmental profile. Ann Indian Acad Neurol 2014;17:25-9
|How to cite this URL:|
Malhi P, Singhi P. A retrospective study of toddlers with autism spectrum disorder: Clinical and developmental profile. Ann Indian Acad Neurol [serial online] 2014 [cited 2019 Jul 17];17:25-9. Available from: http://www.annalsofian.org/text.asp?2014/17/1/25/128537
| Introduction|| |
Autism spectrum disorders (ASD) are neurodevelopmental disorders which are characterized by qualitative deficits in areas of reciprocal social interaction, verbal and non-verbal communication, and a preference for repetitive, stereotyped behaviors and interests. These characteristics must be present before 3 years of age in order to meet the Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria for an ASD diagnosis.  Recent reviews of ASD epidemiological studies have reported higher estimates of incidence and prevalence than earlier studies and the current median ASD prevalence estimate is about 62 in 10,000. ,
One of the key research priorities in autism research is on the identification of early biological and behavioral signs or symptoms of ASD, as it is hoped that this would facilitate the identification of underlying genetic and neurobiological mechanisms, improve early screening, and provide an impetus to research focused on behavioral or biological treatment. ,, Moreover, considerable evidence has accumulated to support the finding that early interventions in children with ASD lead to immense improvement in language, cognition, and behavior functioning. 
Despite the fact that symptoms of autism present early, the age of diagnosis is typically not before 4 years. In India, most children with ASD are diagnosed between 3 and 6 years of age. ,, For instance, Daley, in a study of 98 ASD children in India, found that parents reported recognizing symptoms at an average age of 26 months and spent on an average of 2 years between the time they initially recognized the child's problems and took the child to a clinician and had it diagnosed. Parents, on an average, reported consulting 3.5 clinicians before receiving a reliable diagnosis.  Moreover, studies indicate that many children may get wrong diagnostic labels such as Attention Deficit Hyperactivity Disorder (ADHD) or mental retardation. , A number of factors have been implicated in delayed diagnosis, including limited knowledge of ASD among physicians, lack of awareness regarding screening and diagnostic ASD instruments for young children, and doubts about the validity of an early diagnosis of ASD. ,, Most parents also express early concerns about the development of their children and notice behavioral abnormalities generally in the first 2 years of life. ,, However, confirmation of diagnosis does not occur till 3-4 years of age or later, and this often results in extended period of time before referring families of children with ASD to specialists for assessment. ,
There is no study from India which has examined the clinical and developmental profile of autism in toddlers. Keeping this in mind, the aim of the study was to retrospectively examine the developmental and clinical characteristics of children with ASD in the first 2 years of life in order to narrow the interval between parental concern and getting a reliable diagnosis of autism.
| Materials and Methods|| |
The participants in the study included 21 (19 boys, 2 girls) children in whom a diagnosis of ASD was made at age 2 years or less. The inclusion criteria for all children were a chronological age of 2 years or less, absence of neurological, metabolic, or genetic disorders, and absence of sensory or motor impairment. The case records of these children were maintained in the Pediatric Psychology Clinic at the Department of Pediatrics of a tertiary care teaching hospital in North India. All the children had received multidisciplinary evaluations that included neurological, diagnostic, cognitive, and behavioral assessments. Information regarding socioeconomic and demographic variables such as household income, number of years of parental education, IQ scores, scores on the Childhood Autism Rating Scale (CARS), scores on the Vineland Social Maturity Scale, and scores on the Developmental Profile II (DP II) was available for all the participants, as these measures are routinely administered to all children in whom a diagnosis of ASD is made. Scores on the Modified Checklist for Autism in Toddlers (M-CHAT) were available for only those children in whom a diagnosis of ASD was made after 2003 (n = 16). All the scales were individually administered to the parents by the first author. A description of the sample characteristics is presented in [Table 1]. All analyses were done using the SPSS 13.0 statistical software.
A detailed developmental assessment was done using DP II,  which is a 186-item inventory to assess the child's developmental status from birth to 9½ years. The DP II assesses child's developmental age in five domains, namely, physical, social, self-help, academic, and communication. One of the most important features of DP II is that its academic scale can be converted into an IQ score. The academic scale assesses a range of skills necessary for success in school, including language, cognition, and scholastic accomplishments. The IQ calculated from the academic scale has been found to have moderate to high correlation with conventional measures of intelligence. In the present study, the IQ of the subjects was calculated from the academic subscale of DP II.
Vineland Social Maturity Scale
The adaptive behavior of the child was measured by the Indian adaptation of the Vineland Social Maturity Scale.  The scale yields two scores, social age and social quotient (SQ). The SQ is a measure of a child's social competence and the ability to perform daily living tasks.
The CARS is a 15-item rating scale which elicits information on the child's behavior with respect to socialization, communication, emotional responses, and sensory sensitivities.  The child is rated on each item based on the clinician's observation of the child's behavior throughout the evaluation, as well as on the report of the parent. Each item is scored on a range from normal, scored as 1, to severely abnormal, scored as 4. Scores for all the 15 items are summed to yield a total score that ranges from 15 to 60. The cut-off score for diagnosis of autism is 30. Scores from 30 to 37 are categorized as mildly/moderately autistic and scores above 37 are categorized as severely autistic.
The M-CHAT is a parent-report 23-item questionnaire that is used to screen for autism in children aged between 18 and 30 months.  Each item is to be scored as yes or no. M-CHAT is considered failed (screen positive) if any 3 of the 23 items failed, or any 2 of the 6 critical items failed and these include items concerning joint attention (proto-declarative pointing, bringing to show, following a point), interest in other children, responding to name, and imitation.
Kuppuswamy socioeconomic status scale
The revised Kuppuswamy socioeconomic status scale was used to assess the socioeconomic status (SES) of the family.  The scale assigns different scores to different levels of education, occupation, and income of the family members, with higher scores indicating higher SES. Based on the total score of each family, five categories of socioeconomic groups are identified: Upper, upper middle, lower, middle, upper lower, and lower.
Diagnosis of autism
The diagnosis of autism was made independently by the two authors, a psychologist and a pediatric neurologist, both of whom have considerable experience in the diagnosis of autism and related developmental disorders. The authors used DSM IV criteria  to base their clinical judgment. Clinical judgment by experienced clinicians is considered to be the gold standard for an ASD diagnosis. , Only those cases were labeled as ASD in whom there was a consensus between the two authors regarding the diagnosis.
| Results|| |
A total of 33 children were diagnosed with ASD at 2 years or less (from 1999 to 2012). However, in the present study, the clinical and developmental profile of only 21 children, i.e. those without a history of significant medical and genetic problems, is being presented. This is primarily being done in order to study the early features of autism in a more homogenous and neurologically normal sample of young children. Twelve children were therefore excluded. Out of the excluded children, six had infantile spasms, one had hypothyroidism, one had impaired vision, and three had abnormal magnetic resonance imaging (MRI) findings. Out of the 21 ASD children included, majority were diagnosed as having Autistic Disorder (n = 20) and only 1 child was assigned the diagnostic label of Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). The average age at presentation to the clinic was 21.23 months (SD = 2.18) and only one child was less than 18 months. The ASD diagnosis was confirmed 6-12 months after the initial evaluation. A little less than two-thirds of the toddlers with ASD had CARS score in the severe range (M = 37.21, SD = 3.54).
The frequencies of reported characteristics of ASD children of age 2 years or less for the total sample and by the severity of autism as assessed by the CARS, i.e. mild/moderate severity (total scores on CARS less than 37) and severe ASD (total scores on CARS 37 and above), are presented in [Table 2]. The clinical characteristics which were found in two-thirds or more children included no meaningful speech (95.2%), little interest in children (95.2%), no index finger pointing (90.5%), motor stereotypies (85.7%), lack of joint attention (81%), inability to follow verbal commands (81%), lack of pretend play (81%), inability of the child to follow language (81%), unusual play (71.4%), and poor eye contact (66.7%). Children with severe autism, as defined by the CARS scores, as compared to the children with mild autism, were more likely to show poor response to name (χ2 = 6.10, P = 0.013), have delayed motor milestones (χ2 = 5.25 P = 0.022), and display lack of a social smile (χ2 = 6.10, P = 0.013).
|Table 2: Frequencies (%) of reported characteristics for the total sample and by severity of ASD symptoms|
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The ASD children displayed a wide variety of repetitive stereotypic behaviors involving the body and objects, including rocking, hand flapping, hand gazing, spinning, and toe walking. Non-functional manipulation of objects was reported including spinning, mouthing, banging objects, licking surfaces, banging doors, twirling ropes, holding objects, lining and stacking, and repetitive manipulation of objects. Little more than one-fourth of the children (28.6%) displayed self-injurious behavior such as repetitive head banging or slapping self.
The M-CHAT scores were available for only 16 children. All the ASD children failed the M-CHAT. The mean number of total items failed was 13.31 (SD = 4.01) and the mean number of critical items failed was 4.25 (SD = 1.53). The IQ scores of the children were based on the DP II academic scale. The mean IQ was 66.62 (SD = 15.11). Twelve children (57.1%) were cognitively delayed (IQ less than 70), one had borderline cognitive abilities (IQ of 70-79), and eight (38.1%) had IQs in the average range of intellectual functioning (IQ of 80 and above). The mean SQ as measured by the Vineland Social Maturity Scale was 80.43 (SD = 17.45). Twelve (57.1%) children had SQs in the average range of adaptive functioning (SQ of 80 and above) and only 5 (23.8%) had SQs less than 70. The most common concerns expressed by the parents at initial presentation were delay in language (66.7%, n = 14), motor delay (23.8%, n = 5), and odd behavior (9.5%, n = 2). Problems related to poor social interaction were not reported spontaneously by any parent. Four parents (19%) also reported developmental regression in their children.
| Discussion|| |
In this study, we report on the clinical characteristics of children diagnosed with ASD at age 2 years or less. The diagnosis of ASD in very young children is challenging, although recent research has documented that the diagnosis of ASD in toddlers is valid and stable over time. , The clinical characteristics found in the majority of the ASD children included lack of joint attention, unusual play, lack of pretend play, no index finger pointing, difficulty in playing with toys in a constructive manner, inability of the child to follow language, motor stereotypies, and poor eye contact. However, we need to keep in mind that the sample size is relatively small and the results need to be replicated using larger samples. Our findings support previous research which had examined early signs and symptoms of autism in infants and toddlers using a retrospective methodology, including examining of home videotapes of children already diagnosed with ASD  or using retrospective questionnaires and interviews asking parents to recall the early abnormal behaviors of children with ASD.  These studies have shown that behaviors that consistently discriminate toddlers with autism from those with non-autism developmental delays or typical development are orienting to name, eye contact, social referencing, interest in other children, joint attention, affect sharing, and imitation. ,
Nearly one-third of the toddlers with ASD had motor delays. History of delayed motor development was more prevalent in children with severe ASD. Our findings support previous studies reporting that 50-75% ASD children have significant motor delays compared to normative children.  For example, Provost et al. assessed motor delay in ASD children aged 21-41 months, and compared their motor scores to those of children without ASD and found that all children with ASD had delays in gross motor skills, fine motor skills, or both.
An overwhelming majority of the ASD children of age 2 years or younger displayed unusual preoccupations, hand and finger mannerisms, and repetitive use of objects. These findings confirm the findings of previous studies. , For instance, Watt et al. found that young ASD children aged 18-24 months demonstrated significantly higher frequency and longer duration of repetitive stereotypic behaviors as compared to children with developmental delay and children with typical development. In fact, repetitive stereotypic behaviors were found to predict developmental outcomes and severity of autism symptoms at 3 years. It seems then that early stereotypic behaviors in the second year are important not only for early identification but also for the prediction of developmental outcomes.
Most parents reported speech delay and inability to follow verbal commands as their main concern for seeking medical help. Previous studies have documented that the most common and first noted concerns are delays in speech and language development, followed by abnormal social responsivity level, medical problems, and behavioral difficulties related to sleeping, eating, and hyperactivity.  It is noteworthy that parental concerns related to core ASD symptoms such as social deficits were not raised spontaneously by any parent. Clearly then, parents may raise concerns which may not be very specific to the core symptoms of autism and by themselves may not be reliable markers of an ASD diagnosis.  Four different onset patterns in autism have been described in the literature, including very early onset of symptoms without skill loss, late onset of symptoms seen in children with loss of developmental milestones without early symptoms, early onset combined with later skill loss, and late onset without any skill loss. Therefore, it has been suggested in the literature that ASD children may reach the threshold for diagnosis at different ages in the first 3 years of life depending on early or late presentation of symptoms with or without regression. , Autistic regression has been reported in 20-40% of the cases in previous studies. , It is noteworthy that a significant proportion of the parents reported loss of developmental milestones in their children, particularly in the language and social domain.
Despite the growing evidence of diagnostic stability, providing reliable diagnoses of ASD can be challenging in very young children. Our study suggests that signs of autism emerge over the first 2 years of life for a large proportion of children with ASD. Given the validity of early diagnosis over time, clinicians should be educated regarding the early signs and encouraged to make a timely diagnosis. Earlier identification would enable ASD children to enroll in intervention services sooner, which would result in improved outcomes.
| References|| |
|1.||American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4 th ed. Washington D.C: American Psychiatric Association; 1994. |
|2.||Fombonne E. The prevalence of autism. JAMA 2003;289:87-9. |
|3.||Elsabbagh M, Divan G, Koh YJ, Kim YS, Kauchali S, Marcín C, et al. Global prevalence of autism and other pervasive developmental disorders. Autism Res 2012;5:160-79. |
|4.||Elsabbagh M, Johnson MH. Getting answers from babies about autism. Trends Cogn Sci 2010;14:81-7. |
|5.||Macari SL, Campbell D, Gengoux GW, Saulnier CA, Klin AJ, Chawarska K. Predicting developmental status from 12 to 24 months in infants at risk for autism spectrum disorder: A preliminary report. J Autism Dev Disord 2012;42:2636-47. |
|6.||Chawarska K, Macari S, Shic F. Decreased spontaneous attention to social scenes in 6-month-old infants later diagnosed with autism spectrum disorders. Biol Psychiatry 2013;74:195-203. |
|7.||Boyd BA, Odom SL, Humphreys BP, Ann M, Sam AM. Infants and toddlers with autism spectrum disorder: Early identification and early intervention. J Early Interv 2010;32:75-98. |
|8.||Malhi P, Singhi P. Recognition of autism in young children. Stud Psychol 2003;45:75-80. |
|9.||Kalra V, Seth R, Sapra S. Autism experiences in a tertiary care hospital. Indian J Pediatr 2005;72:227-30. |
|10.||Daley TC. From symptom recognition to diagnosis: Children with autism in urban India. Soc Sci Med 2004;58:1323-35. |
|11.||Singhi P, Malhi P. Clinical and neuro developmental profile of young children with autism. Indian Pediatr 2001;38:384-90. |
|12.||Chawarska K, Paul R, Klin A, Hannigen S, Dichtel LE, Volkmar F. Parental recognition of developmental problems in toddlers with autism spectrum disorders. J Autism Dev Disord 2007;37:62-72. |
|13.||Malhi P, Singhi P. Can parental concerns distinguish very young autistic from non-autistic children? Psychol Stud 2008;53:339-43. |
|14.||Hess CR, Landa RJ. Predictive and concurrent validity of parent concern about young children at risk for autism. J Autism Dev Disord 2012;42:575-84. |
|15.||Zwaigenbaum L, Bryson S, Rogers T, Roberts W, Brian J, Szatmari P. Behavioral manifestation of autism in the first year of life. Int J Dev Neurosci 2005;23:143-52. |
|16.||Alpern B, Boll T, Shearer M. Developmental Profile II (DP II). Los Angeles CA: Western Psychological Services; 1986. |
|17.||Malin AJ. The Indian adaptation of the Vineland Social Maturity Scale. Lucknow, India: Indian Psychological Corporation; 1971. |
|18.||Schopler E, Reichler R, Rochen Renner B. The Childhood Autism Rating Scale. Los Angeles, CA: Western Psychological Services; 1988. |
|19.||Robins DL, Fein D, Barton ML, Green JA. The Modified Checklist for Autism in Toddlers: An initial study investigating the early detection of autism and pervasive developmental disorders. J Autism Dev Disord 2001;31:131-44. |
|20.||Kumar N, Shekhar C, Kumar P, Kundu AS. Kuppuswamy′s socioeconomic status scale- updating for 2007. Indian J Pediatr 2007;74:1131-2. |
|21.||Klin A, Lang J, Cicchetti DV, Volkmar, FR. Brief report: Inter-rater reliability of clinical diagnosis and DSM-IV criteria for autistic disorder: Results of the DSM-IV autism field trial. J Autism Dev Disord 2000;30:163-7. |
|22.||Volkmar F, Chawarska K, Klin A. Autism in infancy and early childhood. Annu Rev Psychol 2005;56:315-36. |
|23.||Kleinman JM, Ventola PE, Pandey J, Verbalis AD, Barton M, Hodgson S, et al. Diagnostic stability in very young children with autism spectrum disorders. J Autism Dev Disord 2008;38:606-15. |
|24.||Chawarska K, Klin A, Paul R, Macari S, Volkmar F. A prospective study of toddlers with ASD: Short-term diagnostic and cognitive outcomes. J Child Psychol Psychiatry 2009;50:1235-45. |
|25.||Werner E, Dawson G, Osterling J, Dinno N. Brief report: Recognition of autism spectrum disorder before one year of age: A retrospective study based on home videotapes. J Autism Dev Disord 2000;30:157-62. |
|26.||Ozonoff S, Iosif AM, Baguio F, Cook IC, Hill MM, Hutman T, et al. A prospective study of the emergence of early behavioral signs of autism. J Am Acad Child Adolesc Psychiatry 2010;49:256-66. |
|27.||Zwaigenbaum L. Advances in the early detection of autism. Curr Opin Neurol 2010;23:97-102. |
|28.||Mayes SD, Calhoun SL. Ability profiles in children with autism: Influence of age and IQ. Autism 2003;7:65-80. |
|29.||Provost B, Lopez BR, Heimerl S. A comparison of motor delays in young children: Autism spectrum disorder, developmental delay, and developmental concerns. J Autism Dev Disord 2007;37:321-8. |
|30.||MacDonald R, Green G, Mansfiled R, Geckeler A, Gardenier N, Anderson J, et al. Stereotypy in young children with autism and typically developing children. Res Dev Disabil 2007;28:266-77. |
|31.||Watt N, Wetherby AM, Barber A, Morgan L. Repetitive and stereotyped behaviors in children with autism spectrum disorders in the second year of life. J Autism Dev Disord 2008;38:1518-33. |
|32.||Malhi P, Singhi P. Regression in children with autism spectrum disorders. Indian J Pediatr 2012;79:1333-7. |
|33.||Landa RJ, Gross AL, Stuart EA, Faherty A. Developmental trajectories in children with and without autism spectrum disorders: The first 3 years. Child Dev 2013;84:429-42. |
[Table 1], [Table 2]