LETTER TO THE EDITOR
|Year : 2015 | Volume
| Issue : 1 | Page : 129
Tuberculous meningitis on directly observed thrice a week regime
Sora Yasri1, Viroj Wiwanitkit2
1 KMT Primary Care Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, Haikou, Hainan, China
|Date of Web Publication||10-Feb-2015|
KMT Primary Care Center, Bangkok
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Yasri S, Wiwanitkit V. Tuberculous meningitis on directly observed thrice a week regime. Ann Indian Acad Neurol 2015;18:129
The recent on "tuberculous meningitis on directly observed thrice a week regime" is interesting.  Iype et al., noted that "RNTCP regimen was associated with good compliance, comparable mortality and morbidity. " In fact, Iype et al., has ever reported a highly similar observation in Indian Journal of Tuberculosis and concluded that the new regime is not different from classical regime.  In fact, although the intermittent short course regime might seem convenient,the efficacy of this regime is still inconclusive. According to the meta-analysis, it is concluded that "Trials conducted to date are insufficient to support or refute the use of intermittent twice- or thrice-weekly, short-course treatment regimens over daily short-course treatment. " In addition, the efficacy of the regime in cases with concomitant illness especially for HIV infection should be further systematically studied.
| References|| |
Iype T, Pillai AK, Cherian A, Nuju ZT, Pushpa C, Dae D, Krishnapillai V. Major outcomes of patients with tuberculous meningitis on directly observed thrice a week regime. Ann Indian Acad Neurol 2014;17:281-6.
Iype T, George LE, Cherian A, Kumar A, Ajitha BK, Chandy S, et al
. In-hospital mortality of intermittent vs daily antitubercular regimen in patients with meningeal tuberculosis--a retrospective study. Indian J Tuberc 2012;59:6-11.
Bose A, Kalita S, Rose W, Tharyan P. Intermittent versus daily therapy for treating tuberculosis in children. Cochrane Database Syst Rev 2014;1:CD007953.