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LETTER TO THE EDITOR
Year : 2015  |  Volume : 18  |  Issue : 1  |  Page : 129
 

Tuberculous meningitis on directly observed thrice a week regime


1 KMT Primary Care Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, Haikou, Hainan, China

Date of Web Publication10-Feb-2015

Correspondence Address:
Sora Yasri
KMT Primary Care Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.144316

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How to cite this article:
Yasri S, Wiwanitkit V. Tuberculous meningitis on directly observed thrice a week regime. Ann Indian Acad Neurol 2015;18:129

How to cite this URL:
Yasri S, Wiwanitkit V. Tuberculous meningitis on directly observed thrice a week regime. Ann Indian Acad Neurol [serial online] 2015 [cited 2019 Aug 17];18:129. Available from: http://www.annalsofian.org/text.asp?2015/18/1/129/144316


Sir,

The recent on "tuberculous meningitis on directly observed thrice a week regime" is interesting. [1] Iype et al., noted that "RNTCP regimen was associated with good compliance, comparable mortality and morbidity. [1]" In fact, Iype et al., has ever reported a highly similar observation in Indian Journal of Tuberculosis and concluded that the new regime is not different from classical regime. [2] In fact, although the intermittent short course regime might seem convenient,the efficacy of this regime is still inconclusive. According to the meta-analysis, it is concluded that "Trials conducted to date are insufficient to support or refute the use of intermittent twice- or thrice-weekly, short-course treatment regimens over daily short-course treatment. [3]" In addition, the efficacy of the regime in cases with concomitant illness especially for HIV infection should be further systematically studied.

 
   References Top

1.
Iype T, Pillai AK, Cherian A, Nuju ZT, Pushpa C, Dae D, Krishnapillai V. Major outcomes of patients with tuberculous meningitis on directly observed thrice a week regime. Ann Indian Acad Neurol 2014;17:281-6.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Iype T, George LE, Cherian A, Kumar A, Ajitha BK, Chandy S, et al. In-hospital mortality of intermittent vs daily antitubercular regimen in patients with meningeal tuberculosis--a retrospective study. Indian J Tuberc 2012;59:6-11.  Back to cited text no. 2
    
3.
Bose A, Kalita S, Rose W, Tharyan P. Intermittent versus daily therapy for treating tuberculosis in children. Cochrane Database Syst Rev 2014;1:CD007953.  Back to cited text no. 3
    




 

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