Annals of Indian Academy of Neurology
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Year : 2015  |  Volume : 18  |  Issue : 1  |  Page : 93-95

Spinocerebellar ataxia-10 with paranoid schizophrenia

1 Department of Neurology, Olive View Medical Center, Sylmar, USA
2 Department of Neurology, Harbor Medical Center, Torrance, USA
3 Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, USA

Correspondence Address:
Shrikant Mishra
MD, MS, FAAN, FANA 16111 Plummer Street, North Hills, California - 91343
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.144285

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Spino-cerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that is characterized by cerebellar ataxia, seizures and nystagmus with a fragmented pursuit. Schizophrenia has been reported with SCAs 1 and 2 yet in SCA 10, psychiatric manifestations are uncommon. We report a Hispanic family involving a father and his four children with SCA10 genetic mutation. Two of his children, a 20-year-old female and a 23-year-old male, presented with gradually progressive spino-cerebellar ataxia and paranoid schizophrenia. Neurological examination revealed ocular dysmetria, dysdiadokinesia, impaired finger-to-nose exam, gait ataxia and hyperreflexia in both the cases. Additionally, they had a history of psychosis with destructive behavior, depression and paranoid delusions with auditory hallucinations. Serology and CSF studies were unremarkable and MRI brain revealed cerebellar volume loss. Ultimately, a test for ATAXIN-10 mutation was positive thus confirming the diagnosis of SCA10 in father and his four children. We now endeavor to investigate the association between schizophrenia and SCA10.

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