Annals of Indian Academy of Neurology
  Users Online: 634 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
CASE REPORT
Year : 2015  |  Volume : 18  |  Issue : 1  |  Page : 93-95

Spinocerebellar ataxia-10 with paranoid schizophrenia


1 Department of Neurology, Olive View Medical Center, Sylmar, USA
2 Department of Neurology, Harbor Medical Center, Torrance, USA
3 Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, USA

Correspondence Address:
Shrikant Mishra
MD, MS, FAAN, FANA 16111 Plummer Street, North Hills, California - 91343
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.144285

Rights and Permissions

Spino-cerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that is characterized by cerebellar ataxia, seizures and nystagmus with a fragmented pursuit. Schizophrenia has been reported with SCAs 1 and 2 yet in SCA 10, psychiatric manifestations are uncommon. We report a Hispanic family involving a father and his four children with SCA10 genetic mutation. Two of his children, a 20-year-old female and a 23-year-old male, presented with gradually progressive spino-cerebellar ataxia and paranoid schizophrenia. Neurological examination revealed ocular dysmetria, dysdiadokinesia, impaired finger-to-nose exam, gait ataxia and hyperreflexia in both the cases. Additionally, they had a history of psychosis with destructive behavior, depression and paranoid delusions with auditory hallucinations. Serology and CSF studies were unremarkable and MRI brain revealed cerebellar volume loss. Ultimately, a test for ATAXIN-10 mutation was positive thus confirming the diagnosis of SCA10 in father and his four children. We now endeavor to investigate the association between schizophrenia and SCA10.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1950    
    Printed35    
    Emailed0    
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal