Annals of Indian Academy of Neurology
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Year : 2015  |  Volume : 18  |  Issue : 4  |  Page : 459-463

Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis

1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Hematology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Kameshwar Prasad
Professor and Head, Department of Neurology, Neuroscience Centre, Room No. 704, 7th Floor, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.165482

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Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS), which is disabling and majorly involves younger population. Various available treatments in forms of immunomodulation are not very effective; however, stem cell transplantation seems to be promising in recent literature. The current case report is a novel evidence for autologous hematopoietic stem cell transplantation (HSCT) in progressive MS. Case Summary: A 33 year old male with secondary progressive MS (SPMS), after being failed and/or intolerance to standard approved interferon (IFN) and mitoxantrone therapy, autologous HSCT was administered. At 2years of post-stem cell transplantation follow-up, he has remained stable with some improvement in functional status (Expanded Disability Status Scale (EDSS) reduced by 1.5), with no relapse, no treatment related complications, and no fresh magnetic resonance imaging (MRI) lesions. Conclusion: Autologous stem cell transplantation may be beneficial in progressive forms of MS, but needs to be tested in well-designed randomized trial.

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