brintellex
ValprolBanner
Annals of Indian Academy of Neurology
  Users Online: 84 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
ORIGINAL ARTICLE
Year : 2016  |  Volume : 19  |  Issue : 3  |  Page : 344-350

Evaluating the efficacy of memantine on improving cognitive functions in epileptic patients receiving anti-epileptic drugs: A double-blind placebo-controlled clinical trial (Phase IIIb pilot study)


1 Department of Pharmacology, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram, Tamil Nadu, India
2 Department of Neurology, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram, Tamil Nadu, India
3 Department of General Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram, Tamil Nadu, India
4 Department of Clinical Psychology, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram, Tamil Nadu, India
5 Department of Biostatistics, SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram, Tamil Nadu, India

Correspondence Address:
Priya Marimuthu
Department of Pharmacology, SRM Medical College Hospital and Research Centre, Kattankulathur - 603 203, Kancheepuram, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-2327.179971

Clinical trial registration CTRI/2013/04/003573

Rights and Permissions

Objectives: People with epilepsy have greater cognitive and behavioral dysfunction than the general population. There is no specific treatment available for cognitive impairment of these patients. We aimed to evaluate the effects of memantine, an N-methyl-D-aspartate-type glutamate receptor noncompetitive antagonist, on improving cognition and memory functions in epileptic patients with cognitive and memory impairment, who received anti-epileptic drugs (AEDs). Methods: We did a randomized, double-blind, placebo-controlled parallel group trial, in SRM Medical College Hospital and Research Centre, Kattankulathur, Kancheepuram, Tamil Nadu, India between April 2013 and September 2013. Fifty-nine epileptic patients taking AEDs with subjective memory complaints were recruited and randomized to either Group 1 to receive 16 weeks of once-daily memantine, (5 mg for first 8 weeks, followed by memantine 10 mg for next 8 weeks) or Group 2 to receive once daily placebo. This trial is registered with Clinical Trial Registry of India CTRI/2013/04/003573. Results: Of 59 randomized patients, 55 patients completed the study (26 memantine and 29 placebo). Memantine group showed statistically significant improvement in total mini mental state examination score from baseline (P = 0.765) to 16 th week (P < 0.001) in comparison with the placebo. The Weshler's Memory Scale total score in memantine group improved significantly after 8 weeks (P = 0.002) compared with baseline (P = 0.873) and highly significant at the end of 16 th week (P < 0.001). The self-rated quality of life and memory in memantine group also significantly improved at the study end. Conclusion: We conclude that once-daily memantine (10 mg) treatment significantly improved cognition, memory and quality of life in epileptic patients with mild to moderate cognitive impairment and was found to have a favorable safety profile.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3185    
    Printed92    
    Emailed0    
    PDF Downloaded106    
    Comments [Add]    

Recommend this journal