Annals of Indian Academy of Neurology
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Year : 2020  |  Volume : 23  |  Issue : 2  |  Page : 223-224

Chorea and parkinsonism with elevated striational antibody

1 Department of Neurology, Kansas University Medical Center, Kansas City, Kansas, USA
2 Neurologist, Department of Neurology, Stormont Vail Health, Manhattan, Kansas, USA

Correspondence Address:
Dr. Harsh V Gupta
Assistant Professor of Neurology, Kansas University Medical Center, Kansas City, Kansas - 66160
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aian.AIAN_364_19

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Subacute onset of a mixed movement disorder should alert the clinician to the possibility of an autoimmune or paraneoplastic cause of symptoms. Striational antibodies have been associated with myasthenia gravis but a mixed movement disorder has been rarely reported with this antibody. We report a 90-year-old female who presented with generalized chorea, blepharospasm, and parkinsonism. Extensive evaluation was done which showed an elevation in striational antibody and there was no evidence of malignancy. The patient responded dramatically to intravenous steroids. We suggest that striational antibody should be routinely tested as a part of the work-up for autoimmune or paraneo lastic movement disorder. The presence of chorea in a very elderly patient should not be dismissed as “senile chorea” and a search for treatabl etiology should always be performed.

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