brintellex
ValprolBanner
Annals of Indian Academy of Neurology
  Users Online: 189 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size

Table of Contents
LETTER TO THE EDITOR
Year : 2020  |  Volume : 23  |  Issue : 3  |  Page : 378-379
 

Ipsilesional torsional nystagmus in midbrain infarction: A rare entity of localizing value


1 Department of Neurology, Lady Hardinge Medical College, New Delhi, India
2 Department of Medicine, Lady Hardinge Medical College, New Delhi, India

Date of Submission05-Dec-2019
Date of Acceptance15-Dec-2019
Date of Web Publication09-May-2020

Correspondence Address:
Dr. Divyani Garg
Department of Neurology, Lady Hardinge Medical College, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aian.AIAN_646_19

Rights and Permissions

 



How to cite this article:
Garg D, Gupta A, Dhamija RK. Ipsilesional torsional nystagmus in midbrain infarction: A rare entity of localizing value. Ann Indian Acad Neurol 2020;23:378-9

How to cite this URL:
Garg D, Gupta A, Dhamija RK. Ipsilesional torsional nystagmus in midbrain infarction: A rare entity of localizing value. Ann Indian Acad Neurol [serial online] 2020 [cited 2020 Jul 8];23:378-9. Available from: http://www.annalsofian.org/text.asp?2020/23/3/378/284071




Sir,

The midbrain is home to the control of vertical and torsional gaze. The rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) contains excitatory burst neurons (EBN) that generate vertical and ipsiversive saccades.[1]

A 50-year-old male presented to our neurology clinic with a sudden onset of rotatory vertigo and vertical diplopia 3 days prior to presentation. He was a hypertensive on irregular treatment. On examination, he was alert and well-oriented. Higher mental functions were normal. Oculomotor abnormalities were noted in the form of right eye hypertropia and left eye hypotropia. He had torsional nystagmus (TN) at midposition combined with a vertical component. The quick phase of torsional nystagmus showed rotation of the upper poles to the right (that is, excyclotorsion of the right eye and incyclotorsion of the left eye) in a clockwise direction for the patient [Video 1]. Vertical nystagmus component in gaze straight ahead was upward [Figure 1]. He showed combined up- and downward saccade slowing. There was vertical gaze paresis (down > up). Head tilt was to the left. There was a normal pupillary reaction to light. There was neither convergence-retraction nystagmus nor an eyelid retraction. There was mild swaying to the right on tandem gait and the left plantar was extensor. Other neurological and systemic examinations were unremarkable. His blood pressure was 146/88 mmHg. Complete hemogram, renal, hepatic, and thyroid functions were normal. Magnetic resonance imaging (MRI) of the brain showed an acute infarct in the right caudal midbrain involving the cerebral peduncle and the tegmental regions [Figure 2]a and [Figure 2]b. He was treated with antiplatelets and statins. The ophthalmologic symptoms resolved completely over the subsequent 2 weeks although he had mild persistent gait swaying.
Figure 1: Diagrammatic representation of nystagmus observed in the patient in right eye (RE) and left eye (LE)

Click here to view
Figure 2: MRI brain showing an acute infarct involving the ventral aspect of the right caudal midbrain on diffusion-weighted imaging (a) and apparent diffusion coefficient (b) sequences

Click here to view







Whereas riMLF on each side sends axons of EBN to yoke muscles on both sides responsible for vertical saccades, the control of torsion is unilateral and ipsiversive.[2] Hence, the right riMLF will cause torsion to the right, or clockwise from the subject's point of view (that is, right eye extorsion and left eye intorsion). The intersitial nucleus of Cajal (iC) projects to the oculomotor neurons through ipsilateral connections as well as via the posterior commissure and is responsible for vertical and torsional gaze-holding.[3] Bilateral iC lesions will lead to vertical gaze-evoked nystagmus, impaired vertical and torsional vestibulo-ocular reflex as well as vertical saccade restriction with normal speed within the limited range. Unilateral iC lesions produce ipsiversive torsional nystagmus and contraversive ocular tilt reaction (OTR).[4] Hence, the directionality of the TN helps to distinguish riMLF lesions from iC lesions. Torsional nystagmus is defined as ipsilesional if the rotation occurs in the direction of the lesion, as in our patient. As such, torsional nystagmus is uncommon in midbrain lesions and may occur in either direction (ipsi- or contralesional) as previously reported.[5] Clinically, isolated lesions of the riMLF and iC may be distinguished by several features. Unilateral riMLF lesions lead to contralesional TN without vertical gaze-evoked nystagmus, vertical saccade slowing, and a loss of the quick phase of ipsilesional vestibulo-ocular reflex. Unilateral iC lesions lead to ipsilesional TN, vertical gaze-evoked nystagmus but no slowing of the vertical saccades. The localizing value of nystagmus in midbrain lesions has increased with reports that riMLF versus iC may be localized using TN and torsional saccadic assessment. In a series of 11 patients reporting TN in midbrain lesions, eight patients were found to have contralesional TN and only three to have ipsilesional TN.[5] The clinical findings that our patient exhibited were a combination predominantly of riMLF and iC lesions, similar to case 11 in the abovementioned case series.[5] In this series, oculomotor deficits were found to persist for prolonged periods of time, that extended even up to one year. However, in our case, the resolution of the oculomotor abnormalities occurred over the succeeding 10–14 days [Video 2].






The presence of torsional nystagmus in association with other ocular abnormalities helps provide localizing pointers in midbrain lesions.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Buttner-Ennever JA. Mapping the oculomotor system. Prog Brain Res 2008;171:3-11.  Back to cited text no. 1
    
2.
Moschovakis AK, Scudder CA, Highstein SM. A structural basis for Hering's law: Projections to extraocular motoneurons. Science 1990;248:1118-9.  Back to cited text no. 2
    
3.
Crawford JD, Cadera W, Vilis T. Generation of torsional and vertical eye position signals by the interstitial nucleus of Cajal. Science 1991;252:1551-3.  Back to cited text no. 3
    
4.
Kokkoroyannis T, Scudder CA, Balaban CD, Highstein SM, Moschovakis AK. Anatomy and physiology of the primate interstitial nucleus of Cajal I. Efferent projections. J Neurophysiol 1996;75:725-39.  Back to cited text no. 4
    
5.
Helmchen C, Rambold H, Kempermann U, Buttner-Ennever JA, Buttner U. Localizing value of torsional nystagmus in small midbrain lesions. Neurology 2002;59:1956-64.  Back to cited text no. 5
    


    Figures

  [Figure 1], [Figure 2]



 

Top
Print this article  Email this article

    

 
   Search
 
  
    Similar in PUBMED
    Article in PDF (505 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    References
    Article Figures

 Article Access Statistics
    Viewed70    
    Printed1    
    Emailed0    
    PDF Downloaded5    
    Comments [Add]    

Recommend this journal