Annals of Indian Academy of Neurology
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Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis


1 Isfahan Medical Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Immunology, Feiz Eye Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Neurology, School of Medicine, Feiz Eye Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
4 Isfahan Medical Students Research Center, Isfahan University of Medical Sciences; Department of Ophthalmology, Feiz Eye Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Fereshteh Alsahebfosoul,
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aian.AIAN_515_18

Background: Multiple sclerosis (MS) is a chronic demyelinating disorder of central nervous system. Although the definite pathogenesis of MS has not been understood, crucial role of environmental and genetic risk factors has been proposed. Propose: To determine the serum level of interleukin-18 (IL-18) as well as gene polymorphisms of IL-18 (rs1946518, rs360719, and rs187238). Methods: In this case–control study, 110 MS patients diagnosed according to the McDonald criteria and 110 healthy individuals were recruited. IL-18 gene polymorphisms were genotyped by polymerase chain reaction high-resolution melt test, and IL-18 serum level was determined by enzyme-linked immunosorbent assay technique. Results: The mean age of the MS patients (89 females and 21 males) and the control group (89 females and 21 males) was 30.3 ± 9.25 and 30.28 ± 9.13 years, respectively. The mean serum levels of IL-18 in MS patients and healthy individuals were 341.56 ± 39.22 Pg/Ml and 146.52 ± 29.30 Pg/Ml, respectively (P < 0.001). The genotype of rs1946518 (but not rs360719 and rs187238) was significantly different between groups (P = 0.037 and P = 0.069, respectively). Conclusion: In this study, we showed the significant higher IL-18 serum level and significant different frequencies of two polymorphisms of IL-18 in MS patients. These results show the important roles of IL-18 in MS pathogenesis. However, more studies are needed to verify our results in larger sample size.


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    -  Jahanbani-Ardakani H
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