Annals of Indian Academy of Neurology
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No Evidence of Disease Activity (NEDA) in multiple sclerosis - Shifting the goal posts

 Professor of Neurology, Director of Center for Advanced Neurological Research, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India

Correspondence Address:
Lekha Pandit,
Department of Neurology, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aian.AIAN_159_19

A combined endpoint measure to define no evidence of disease activity (NEDA) is becoming increasingly appealing in the treatment of multiple sclerosis (MS). Initial efforts using a 3 parameter NEDA monitored disease activity using clinical and MRI lesion data. Later refinements, introduced more recently, include brain atrophy measurement and cognitive function analysis in defining NEDA-4. Using these stringent criteria clearly differentiated the usefulness of different disease modifying agents (DMDs) in achieving and sustaining NEDA over time. This in turn has changed attitudes and strategies in management of MS.

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