Annals of Indian Academy of Neurology
  Users Online: 1256 Home | About the Journal | InstructionsCurrent Issue | Back IssuesLogin      Print this page Email this page  Small font size Default font size Increase font size
 
ORIGINAL ARTICLE
Ahead of Print

Rationalization of using the MR diffusion imaging in B12 deficiency


1 Department of Internal Medicine, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
2 Department of Neurosurgery, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
3 Department of Radiology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
4 Department of Neurology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
5 Department of Pharmacy, Rize Education and Research Hospital, Rize, Turkey

Correspondence Address:
Ayhan Kanat,
Department of Neurosurgery, Medical Faculty, Recep Tayyip Erdogan University, 53100 Merkez, Rize
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aian.AIAN_485_18

Context: The structural imaging of brain does not demonstrate any changes in the vast majority of patients with vitamin B12 deficiency, even in the advanced stages. Aims: We investigated the microstructural changes in the brain with diffusion imaging among patients with biochemical evidence of B12 deficiency. Patients and Methods: We retrospectively analyzed all diffusion-weighted MRI images between the periods 2014–2016 who had biochemical evidence of B12. The age-sex matched controls were chosen from the group with normal B12 levels. Patients with pathological findings in conventional MRI images were excluded from the study. Results: About 37 patients were recruited (22 women, 15 men; mean age, 34.1 ± 9.9 years; age range). They were about thirty-four age-and sex-matched controls (with normal B12 levels), which were also included in the study. The mean apparent diffusion coefficient (ADC) value of amygdala (773.8 ± 49.9 vs. 742.2 ± 24.2, P = 0.01), hypothalamus (721.3 ± 39.2 vs. 700.2 ± 38.2, P = 0.02), striate cortex (737.6 ± 77.6 vs. 704.3 ± 58.2, P = 0.04), suprafrontal gyrus (740.7 ± 46.9 vs. 711.6 ± 40.7, P = 0.007) and medulla oblongata-olivary nucleus (787.3 ± 56.4 vs. 759.7 ± 46.2, P = 0.02) were significantly higher in B12 deficiency group compared to controls, whereas ADC values were similar at hippocampus, thalamus, insula, corpus striatum, cingulate gyrus, occipital gyrus, dentate nucleus, cerebral pedicle, tegmentum, pons, and posterior medulla oblongata. Conclusions: Our study indicates that a significant increase in ADC values occurs in multiple brain regions in patients with vitamin B12.


Print this article
 [NEXT]
 [PREV]
 Table of Contents

  Search Pubmed for
 
    -  Polat HB
    -  Kanat A
    -  Celiker FB
    -  Tufekci A
    -  Beyazal M
    -  Ardic G
    -  Turan A
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed96    
    PDF Downloaded6    

Recommend this journal