Annals of Indian Academy of Neurology
CASE REPORT
Year
: 2010  |  Volume : 13  |  Issue : 3  |  Page : 207--210

Dramatic response to infliximab in refractory neurosarcoidosis


Sreekanth Chintamaneni1, Aarat M Patel1, Samuel B Pegram2, Hirenkumar Patel1, Heidi Roppelt1 
1 Department of Rheumatology, Stony Brook University Medical Center, Stony Brook, NY, USA
2 Rheumatic Disease Clinic of Houston, Houston, TX, USA

Correspondence Address:
Sreekanth Chintamaneni
SUNY Stony Brook HSC, Level 16 RM 040, Stony Brook, NY 11794
USA

Sarcoidosis is a systemic disease characterized by noncaseating granulomas in the involved organs. Neurologic manifestations involving the central and/or peripheral nervous system occur in about 5% of patients. Neurosarcoidosis is often refractory to conventional treatment and therefore more effective treatment options are needed. While the etiology of the disease is still unknown, there is now a better understanding of its pathogenesis on a molecular level. It is clear that tumor necrosis factor-α (TNFα) plays a pivotal role in the development of the granulomas and it is believed to be a key cytokine involved in the pathogenesis of the disease. Taking advantage of this better understanding of disease pathogenesis, anti-TNFα agents are being increasingly used to treat refractory sarcoidosis. We report a patient with refractory neurosarcoidosis who showed dramatic improvement in the clinical and radiological manifestations following treatment with infliximab; he suffered a relapse upon discontinuation of the medication.


How to cite this article:
Chintamaneni S, Patel AM, Pegram SB, Patel H, Roppelt H. Dramatic response to infliximab in refractory neurosarcoidosis.Ann Indian Acad Neurol 2010;13:207-210


How to cite this URL:
Chintamaneni S, Patel AM, Pegram SB, Patel H, Roppelt H. Dramatic response to infliximab in refractory neurosarcoidosis. Ann Indian Acad Neurol [serial online] 2010 [cited 2020 May 28 ];13:207-210
Available from: http://www.annalsofian.org/article.asp?issn=0972-2327;year=2010;volume=13;issue=3;spage=207;epage=210;aulast=Chintamaneni;type=0