Annals of Indian Academy of Neurology
REVIEW: PROGRESS IN MEDICINE
Year
: 2013  |  Volume : 16  |  Issue : 3  |  Page : 307--309

A literature review of AD7c-ntp as a biomarker for Alzheimer俟Q製 disease


Jian Zhang, Shengliang Shi 
 Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China

Correspondence Address:
Shengliang Shi
Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, No. 22, Shuang Yong Road, 530021 Nanning, Guangxi
China

The cornerstone of diagnosis of Alzheimer俟Q製 disease (AD) is still the clinical criteria for probable and possible AD established by the NINCDS-ADRDA Work Group in 1984, which had survived for over 27 years. However, with the increase in people俟Q製 knowledge of clinical manifestations and biology of AD, this standard is gradually proving to be insufficient; the early diagnosis of AD is thus particularly important. Therefore, in 2011, the National Institute on Aging and the Alzheimer俟Q製 Association revised the criteria and integrated biomarker evidence into it. Biomarker evidence is expected to enhance the pathophysiological specificity of the diagnosis of AD. According to Consensus Report of the Working Group on Molecular and Biochemical Markers of Alzheimer俟Q製 Disease, a qualified biomarker for AD should have the following abilities: It should detect a fundamental feature of neuropathology and be validated in neuropathologically confirmed cases, reliably with an sensitivity >80% for detecting AD and a specificity >80% for distinguishing other dementias; be reproducible and non-invasive; and be simple to perform and inexpensive. Alzheimer-associated neuronal thread protein (AD7c-NTP) is a member of 非Q裳euronal thread proteins非Q (NTPs); it can be detected in increased concentration in cortical neurons, brain-tissue extracts, cerebrospinal fluid, and urine in the early course of AD neurodegeneration, and it level is proportional to the degree of dementia, which makes it a promising biomarker for AD. In this review, we have evaluated the feasibility of developing AD7c-NTP as a biomarker for AD.


How to cite this article:
Zhang J, Shi S. A literature review of AD7c-ntp as a biomarker for Alzheimer's disease.Ann Indian Acad Neurol 2013;16:307-309


How to cite this URL:
Zhang J, Shi S. A literature review of AD7c-ntp as a biomarker for Alzheimer's disease. Ann Indian Acad Neurol [serial online] 2013 [cited 2020 Aug 8 ];16:307-309
Available from: http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=3;spage=307;epage=309;aulast=Zhang;type=0