Annals of Indian Academy of Neurology
ORIGINAL ARTICLE
Year
: 2014  |  Volume : 17  |  Issue : 1  |  Page : 66--70

Gender influence on selection and outcome of deep brain stimulation for Parkinson俟Q製 disease


Shyambabu Chandran1, Syam Krishnan1, Ravi Mohan Rao1, S Gangadhara Sarma1, P Sankara Sarma2, Asha Kishore1 
1 Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
2 Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India

Correspondence Address:
Asha Kishore
Comprehensive Care Centre for Movement Disorders, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram - 695 011, Kerala
India

Background: Gender differences exist in Parkinson俟Q製 disease (PD), both in clinical manifestations and response to medical treatment. We investigated whether gender differences occur in the clinical characteristics of patients selected for bilateral subthalamic nucleus deep brain stimulation (STN DBS) or in the outcome when resource limits influence treatment choices made by patients. Materials and Methods: Fifty-one consecutive patients were evaluated 1 month before, and 12 months after bilateral STN DBS. All patients were rated using Unified Parkinson俟Q製 Disease Rating Scale, Parkinson俟Q製 Disease Quality of Life (PDQL) Scale, Addenbrooke俟Q製 Cognitive Examination and Beck Depression Inventory. Results: Pre-operative characteristics did not differ between the genders except for lower doses of drugs (P = 0.03), worse emotional scores in PDQL (P = 0.01) and worse depression (P = 0.03) in women. There was no gender difference in the surgical outcome, except a lesser reduction of dopaminergic drugs in women. Depression and quality of life (QOL) improved equally well in women and men. Conclusion: Bilateral STN DBS is equally efficacious in both genders as a treatment for motor complications of PD and for improving QOL. Women are likely to be undertreated because of more severe dyskinesia and may experience less emotional well-being, and could therefore potentially benefit from earlier surgical treatment.


How to cite this article:
Chandran S, Krishnan S, Rao RM, Sarma S G, Sarma P S, Kishore A. Gender influence on selection and outcome of deep brain stimulation for Parkinson's disease.Ann Indian Acad Neurol 2014;17:66-70


How to cite this URL:
Chandran S, Krishnan S, Rao RM, Sarma S G, Sarma P S, Kishore A. Gender influence on selection and outcome of deep brain stimulation for Parkinson's disease. Ann Indian Acad Neurol [serial online] 2014 [cited 2020 Apr 8 ];17:66-70
Available from: http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=1;spage=66;epage=70;aulast=Chandran;type=0