Annals of Indian Academy of Neurology
: 2015  |  Volume : 18  |  Issue : 1  |  Page : 120-

Cerebrospinal fluid cytokines, matrix metalloproteinases, HIV, and tuberculous meningitis

Sim Sai Tin1, Viroj Wiwanitkit2,  
1 Medical Center, Shantou, China
2 Visiting Professor, Hainan Medical University, China; Visiting Professor, Faculty of Medicine, University of Nis, Serbia; Adjunct Professor, Joseph Ayobabalola University, Nigeria; Senior Expert, Surin Rajabhat University, Thailand; Honorary Professor, Dr. Dnyandeo Yashwantrao Patil Medical University, Pune, Maharashtra, India

Correspondence Address:
Sim Sai Tin
Medical Center, Shantou, China

How to cite this article:
Tin SS, Wiwanitkit V. Cerebrospinal fluid cytokines, matrix metalloproteinases, HIV, and tuberculous meningitis.Ann Indian Acad Neurol 2015;18:120-120

How to cite this URL:
Tin SS, Wiwanitkit V. Cerebrospinal fluid cytokines, matrix metalloproteinases, HIV, and tuberculous meningitis. Ann Indian Acad Neurol [serial online] 2015 [cited 2020 Jun 6 ];18:120-120
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Raj et al. reported on "cerebrospinal fluid cytokines, matrix metalloproteinases, HIV and tuberculous meningitis. [1]" Raj et al. noted that "HIV infection did not affect a majority of the CSF cytokines and MMP levels in tuberculous meningitis (TBM) except for IL-1β level. [1]" In fact, many reports show that HIV infection results in alteration of CSFcytokine [2] and matrix metalloproteinases. [3] Juan et al. reported that "CSF INF-gamma levels (>6.4 IU/mL) are very valuable in TBM diagnosis. [4]" The question is why the observation by Raj et al. is different. First, the confounding medical disorders, including to the opportunistic infection, should be well considered. For example, the Cryptococcal meningitis can affect the CSF cytokine, [5],[6] and cytokine therapy is also an alternative treatment for the Cryptococcal meningitis. [7] A further study with control of confounding medical disorder and treatment in HIV-infected cases is suggested.


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