Annals of Indian Academy of Neurology
LETTER TO THE EDITOR
Year
: 2015  |  Volume : 18  |  Issue : 1  |  Page : 120-

Cerebrospinal fluid cytokines, matrix metalloproteinases, HIV, and tuberculous meningitis


Sim Sai Tin1, Viroj Wiwanitkit2,  
1 Medical Center, Shantou, China
2 Visiting Professor, Hainan Medical University, China; Visiting Professor, Faculty of Medicine, University of Nis, Serbia; Adjunct Professor, Joseph Ayobabalola University, Nigeria; Senior Expert, Surin Rajabhat University, Thailand; Honorary Professor, Dr. Dnyandeo Yashwantrao Patil Medical University, Pune, Maharashtra, India

Correspondence Address:
Sim Sai Tin
Medical Center, Shantou, China




How to cite this article:
Tin SS, Wiwanitkit V. Cerebrospinal fluid cytokines, matrix metalloproteinases, HIV, and tuberculous meningitis.Ann Indian Acad Neurol 2015;18:120-120


How to cite this URL:
Tin SS, Wiwanitkit V. Cerebrospinal fluid cytokines, matrix metalloproteinases, HIV, and tuberculous meningitis. Ann Indian Acad Neurol [serial online] 2015 [cited 2019 Nov 19 ];18:120-120
Available from: http://www.annalsofian.org/text.asp?2015/18/1/120/144312


Full Text

Sir,

Raj et al. reported on "cerebrospinal fluid cytokines, matrix metalloproteinases, HIV and tuberculous meningitis. [1]" Raj et al. noted that "HIV infection did not affect a majority of the CSF cytokines and MMP levels in tuberculous meningitis (TBM) except for IL-1β level. [1]" In fact, many reports show that HIV infection results in alteration of CSFcytokine [2] and matrix metalloproteinases. [3] Juan et al. reported that "CSF INF-gamma levels (>6.4 IU/mL) are very valuable in TBM diagnosis. [4]" The question is why the observation by Raj et al. is different. First, the confounding medical disorders, including to the opportunistic infection, should be well considered. For example, the Cryptococcal meningitis can affect the CSF cytokine, [5],[6] and cytokine therapy is also an alternative treatment for the Cryptococcal meningitis. [7] A further study with control of confounding medical disorder and treatment in HIV-infected cases is suggested.

References

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7Jarvis JN, Meintjes G, Rebe K, Williams GN, Bicanic T, Williams A, et al. Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: A randomized controlled trial. AIDS 2012;26:1105-13.