Annals of Indian Academy of Neurology
SHORT COMMUNICATION
Year
: 2016  |  Volume : 19  |  Issue : 4  |  Page : 523--527

Efficacy and tolerability of the modified Atkins diet in young children with refractory epilepsy: Indian experience


Ranju Mehta1, Shaiphali Goel2, Suvasini Sharma2, Puneet Jain3, Sharmila B Mukherjee1, Satinder Aneja2 
1 Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India
2 Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India
3 Department of Neonatal, Pediatric and Adolescent Medicine, Division of Pediatric Neurology, BL Kapur Super Speciality Hospital, New Delhi, India

Correspondence Address:
Suvasini Sharma
Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children«SQ»s Hospital, New Delhi - 110 001
India

Background: The modified Atkins diet (MAD) has been used predominantly in older children, adolescents, and adults. There is a paucity of data on the use of the MAD in refractory epilepsy in young children. Objectives: This study was planned to evaluate the efficacy and tolerability of the MAD in refractory epilepsy in young children. Methods: This study recruited children aged 9 months to 3 years with refractory seizures. Children received MAD for 6-month with the on-going anticonvulsant medications being continued unchanged. Reduction in seizure frequency was the primary outcome measure. Adverse effects were also studied. Results: Thirty-one children with daily seizures were studied with a median age of 18-month (range 9-30 months). West syndrome was the most common epilepsy syndrome (26, 86.6%). Twenty-one children remained on diet at 3 months and 13 at 6 months. The children who achieved >50% seizure reduction were 17 (54.8%) at 3 months and 9 (29%) at 6 months. Refusal to eat was a significant problem seen in eight children. Three children discontinued the diet due to adverse effects. Conclusion: The MAD was found to be feasible, effective, and well-tolerated.


How to cite this article:
Mehta R, Goel S, Sharma S, Jain P, Mukherjee SB, Aneja S. Efficacy and tolerability of the modified Atkins diet in young children with refractory epilepsy: Indian experience.Ann Indian Acad Neurol 2016;19:523-527


How to cite this URL:
Mehta R, Goel S, Sharma S, Jain P, Mukherjee SB, Aneja S. Efficacy and tolerability of the modified Atkins diet in young children with refractory epilepsy: Indian experience. Ann Indian Acad Neurol [serial online] 2016 [cited 2020 Aug 14 ];19:523-527
Available from: http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=4;spage=523;epage=527;aulast=Mehta;type=0