Annals of Indian Academy of Neurology
SHORT COMMUNICATION
Year
: 2020  |  Volume : 23  |  Issue : 2  |  Page : 215--219

Disease severity assessment and short-term outcome in patients with myasthenia gravis


Deepthi Vemuri, Butchi Raju Garuda, S Gopi, T Sateesh Kumar, U Aruna Kumari 
 Department of Neurology, Andhra Medical College/King George Hospital, Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
Dr. Butchi Raju Garuda
Department of Neurology, 2nd Floor, Superspeciality Block, King George Hospital/Andhra Medical College, Maharanipeta, Visakhapatnam - 530 002, Andhra Pradesh
India

Background: Myasthenia gravis (MG) is an autoimmune disorder with a chronic fluctuating course. The outcome measures encapsulate disease severity, functional impact at diagnosis, and objective evaluation of clinical benefit from therapeutic interventions.Aims and Objective: To assess the disease severity, correlation between various outcome measures, and to evaluate the short-term outcome at 3 months and 6 months in a cohort of MG patients.Materials and Methods: Quantitative myasthenia gravis (QMG) score, myasthenia gravis composite (MGC) score, and myasthenia gravis quality of life-15 (MG-QoL-15) score were applied to 54 patients at first visit, 3 months and 6 months follow-up.Results: Mean quality of life-15 (QoL-15) score at base line was 15.241. Mean QMG and MGC scores at baseline were 14.63 ± 8.37 and 15.87 ± 9.14, respectively. QMG score showed a strong positive correlation with both MGC and MG-QoL-15 scores. QMG and MGC scores showed a moderate correlation with acetylcholine receptor antibody (AChR Ab) titers. Mean QMG at follow-up was 9.95 ± 5.49 at 3 months and 6.74 ± 4.74 at 6 months. Mean MGC at follow-up was 10.75 ± 5.58 at 3 months and 6.51 ± 4.36 at 6 months. Conclusion: The combination of physician-evaluated and patient-reported outcome measures provided a more discerning picture of patient status and response to treatment. Incorporating MG outcome measures into clinical practice would aid in modulating therapies.


How to cite this article:
Vemuri D, Garuda BR, Gopi S, Kumar T S, Kumari U A. Disease severity assessment and short-term outcome in patients with myasthenia gravis.Ann Indian Acad Neurol 2020;23:215-219


How to cite this URL:
Vemuri D, Garuda BR, Gopi S, Kumar T S, Kumari U A. Disease severity assessment and short-term outcome in patients with myasthenia gravis. Ann Indian Acad Neurol [serial online] 2020 [cited 2020 May 25 ];23:215-219
Available from: http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=2;spage=215;epage=219;aulast=Vemuri;type=0