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Figure 5: Neuropathological changes in association with IRIS include diffuse myelin pallor (H&E) (a) and massive infiltration by T, CD-8-positive lymphocytes both within the parenchyma (b) and around small blood vessels (c). IRIS may supervene in patients with previous PML (d); in addition, an appearance reminiscent of ADEM may also be found (e), together with massive lymphocytic infiltration. LFB/N.

Figure 5: Neuropathological changes in association with IRIS include diffuse myelin pallor (H&E) (a) and massive infiltration by T, CD-8-positive lymphocytes both within the parenchyma (b) and around small blood vessels (c). IRIS may supervene in patients with previous PML (d); in addition, an appearance reminiscent of ADEM may also be found (e), together with massive lymphocytic infiltration. LFB/N.