Figure 1d: Axial T2-weighted (A, C) and FLAIR images (B, D) show bilateral hyperintense signals in caudate nucleus and putamen. Prion protein (PrPsc) immunostaining on whole mount preparation in coronal plane (E, F) shows strong labeling of caudate nucleus, putamen, medical thalamic nuclei and pulvinar but mild staining in globus pallidum. Note: labeling of lateral geniculate body (LG) and cortical ribbon of cingulate gyrus (CG). Whole mount of striate cortex (G) shows strong diffuse immunolabeling of cortical ribbon for (PrPsc). [E, F, G – Prion protein immunostain (KG9 monoclonal antibody) x1.5]
![Figure 1d: Axial T2-weighted (A, C) and FLAIR images (B, D) show bilateral hyperintense signals in caudate nucleus and putamen. Prion protein (PrPsc) immunostaining on whole mount preparation in coronal plane (E, F) shows strong labeling of caudate nucleus, putamen, medical thalamic nuclei and pulvinar but mild staining in globus pallidum. Note: labeling of lateral geniculate body (LG) and cortical ribbon of cingulate gyrus (CG). Whole mount of striate cortex (G) shows strong diffuse immunolabeling of cortical ribbon for (PrPsc). [E, F, G – Prion protein immunostain (KG9 monoclonal antibody) x1.5]](articles/2009/12/1/images/AnnIndianAcadNeurol_2009_12_1_48_48856_u4.jpg)