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Figure 2: Nerve and muscle biopsy. (a) Sural nerve biopsy showing part of one fascicle with large (*) and small amorphous endoneurial perivascular deposits of amyloid. (be) Muscle biopsy; abundant perimyseal and subperimyseal amyloid at the periphery of a fascicle, partly extending between the myofi bers (b); deposits are congophilic and display apple-green birefringence under the polarizer (c); amyloid deposits are also seen in the intramuscular nerve twig (*) (d) and in the muscle spindle (*) (E). (a and c): Congo red stain; c viewed under polarizer; b, d, and e: H and E stain; ac: 160; d and e: 320, original magnifications)

Figure 2: Nerve and muscle biopsy. (a) Sural nerve biopsy showing part of one fascicle with large (*) and small amorphous endoneurial perivascular deposits of amyloid. (be) Muscle biopsy; abundant perimyseal and subperimyseal amyloid at the periphery of a fascicle, partly extending between the myofi bers (b); deposits are congophilic and display apple-green birefringence under the polarizer (c); amyloid deposits are also seen in the intramuscular nerve twig (*) (d) and in the muscle spindle (*) (E). (a and c): Congo red stain; c viewed under polarizer; b, d, and e: H and E stain; ac: 160; d and e: 320, original magnifications)