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Figure 2 :Schematic representation of functional domains of longest tau isoform (2N4R): The N-terminal projection domain is highly acidic and is followed by proline-rich region that interact with the cytoskeletal elements and plasma membrane to determine the spacing between microtubules in axons and signal transduction. C-terminal microtubule binding domain harbor microtubule binding repeats, pseudorepeats and C-terminal end and appears to regulate the polymerization and stabilization of microtubules

Figure 2 :Schematic representation of functional domains of longest tau isoform (2N4R): The N-terminal projection domain is highly acidic and is followed by proline-rich region that interact with the cytoskeletal elements and plasma membrane to determine the spacing between microtubules in axons and signal transduction. C-terminal microtubule binding domain harbor microtubule binding repeats, pseudorepeats and C-terminal end and appears to regulate the polymerization and stabilization of microtubules