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Figure 3 :Schematic diagram of TDP-43 protein with functional domains: It contains two RNA recognition motifs (RRM 1 and 2) able to bind UG repeats in RNA as well as a glycine-rich C-terminal sequence. These features may be essential for TDP-43 to carry out its role in exon skipping and splicing inhibitory activity, which requires the C-terminal domain of TDP-43 through interaction with several members of the heterogeneous nuclear ribonucleoprotein family associated with mRNA processing. NLS-Nuclear localization sequence, NES-Nuclear export sequence

Figure 3 :Schematic diagram of TDP-43 protein with functional domains: It contains two RNA recognition motifs (RRM 1 and 2) able to bind UG repeats in RNA as well as a glycine-rich C-terminal sequence. These features may be essential for TDP-43 to carry out its role in exon skipping and splicing inhibitory activity, which requires the C-terminal domain of TDP-43 through interaction with several members of the heterogeneous nuclear ribonucleoprotein family associated with mRNA processing. NLS-Nuclear localization sequence, NES-Nuclear export sequence