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Figure 2: Thalamic involvement in limbic seizures. (a) Spontaneous limbic seizure from a rat with limbic epilepsy. Onset is synchronized between the medial dorsal thalamic nucleus and the hippocampus (HC). Time bar is 2 sec. (b) Seizure induced in the HC with direct electrical stimulation. Top trace is baseline recording. Bottom trace follows infusion of inhibitory drug muscimol in medial dorsal nucleus of the thalamus, which results in a significant shortening of seizure duration and prevention of secondary generalization. Infusion adjacent to, but outside the medial dorsal nucleus has no effect on any seizure characteristic. These data demonstrate the involvement of a specific thalamic nucleus in limbic seizures and how precise the placement of the therapeutic intervention has to be. It also demonstrates the importance of the concept of circuit in epilepsy. Time bar is 5 sec

Figure 2: Thalamic involvement in limbic seizures. (a) Spontaneous limbic seizure from a rat with limbic epilepsy. Onset is synchronized between the medial dorsal thalamic nucleus and the hippocampus (HC). Time bar is 2 sec. (b) Seizure induced in the HC with direct electrical stimulation. Top trace is baseline recording. Bottom trace follows infusion of inhibitory drug muscimol in medial dorsal nucleus of the thalamus, which results in a significant shortening of seizure duration and prevention of secondary generalization. Infusion adjacent to, but outside the medial dorsal nucleus has no effect on any seizure characteristic. These data demonstrate the involvement of a specific thalamic nucleus in limbic seizures and how precise the placement of the therapeutic intervention has to be. It also demonstrates the importance of the concept of circuit in epilepsy. Time bar is 5 sec