Indian J Med Microbiol Close
 

Figure 3: Exon including nusinersen ASO recognizes SMN2 exon 7 in pre-mRNA and splices-in exon 7 to produce full length mRNA transcript and SMN protein. SMN, survival motor neuron; mRNA, messenger RNA; C>T, Cytosine to thymine base mutation; ASO, antisense oligonucleotide

Figure 3: Exon including nusinersen ASO recognizes SMN2 exon 7 in pre-mRNA and splices-in exon 7 to produce full length mRNA transcript and SMN protein. SMN, survival motor neuron; mRNA, messenger RNA; C>T, Cytosine to thymine base mutation; ASO, antisense oligonucleotide