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Figure 1: Brain magnetic resonance imaging and pathologic findings. (a) Brain magnetic resonance imaging showing prominent midbrain atrophy. (b) Immunohistochemical staining with antiphosphorylated tau antibody shows diffuse neutrophil threads and tufted astrocytes in the globus pallidus. (c) Globose tangles are seen in the substantia nigra. Immunohistochemical staining using antibodies against α-synuclein and transactive response DNA-binding protein 43 kDa (TDP-43) was negative. Braak neurofibrillary tangle stage = 1. Thal phase (amyloid plaques) = 2. Calibration bar = 100 μm

Figure 1: Brain magnetic resonance imaging and pathologic findings. (a) Brain magnetic resonance imaging showing prominent midbrain atrophy. (b) Immunohistochemical staining with antiphosphorylated tau antibody shows diffuse neutrophil threads and tufted astrocytes in the globus pallidus. (c) Globose tangles are seen in the substantia nigra. Immunohistochemical staining using antibodies against α-synuclein and transactive response DNA-binding protein 43 kDa (TDP-43) was negative. Braak neurofibrillary tangle stage = 1. Thal phase (amyloid plaques) = 2. <i>Calibration bar</i> = 100 μm