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Year : 2012  |  Volume : 15  |  Issue : 4  |  Page : 239-246

Hippocampus in health and disease: An overview

Department of Neurology, Dr. Ram Manohar Lohia, PGIMER- Guru Gobind Singh Indraprasth University, New Delhi, India

Date of Submission28-Mar-2012
Date of Decision29-Apr-2012
Date of Acceptance20-Jun-2012
Date of Web Publication5-Dec-2012

Correspondence Address:
Vikas Dhikav
E Block, Pocket III, sector-18, Flat 280, Paradise Apartment, Rohini New, 110089, India, Rohini
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.104323

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Hippocampus is a complex brain structure embedded deep into temporal lobe. It has a major role in learning and memory. It is a plastic and vulnerable structure that gets damaged by a variety of stimuli. Studies have shown that it also gets affected in a variety of neurological and psychiatric disorders. In last decade or so, lot has been learnt about conditions that affect hippocampus and produce changes ranging from molecules to morphology. Progresses in radiological delineation, electrophysiology, and histochemical characterization have made it possible to study this archicerebral structure in greater detail. Present paper attempts to give an overview of hippocampus, both in health and diseases.

Keywords: AD, atrophy, drug target, early Alzheimer′s, hippocampus, hippocampal atrophy, prevention

How to cite this article:
Anand KS, Dhikav V. Hippocampus in health and disease: An overview. Ann Indian Acad Neurol 2012;15:239-46

How to cite this URL:
Anand KS, Dhikav V. Hippocampus in health and disease: An overview. Ann Indian Acad Neurol [serial online] 2012 [cited 2023 Feb 3];15:239-46. Available from:

   Introduction Top

Hippocampus is an extension of temporal part of cerebral cortex. [1],[2] It can be distinguished externally as a layer of densely packed neurons, which curls into S-shaped structure [Figure 1] on the edge of temporal lobe. Therefore, it is known as a part of limbic lobe (limbic means border). [2] Though lies sub-cortically, it is not totally considered to be a sub-cortical structure. It is a part of hippocampal formation and has many limbs.
Figure 1: Relationship between limbic system and hippocampus. Note that hippocampus is a C-shaped structure having amygdaloid body at its anterior end, culminating deep into mammillary bodies (Figure: courtesy AITBS publishers India)

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This part of brain has been one of the most extensively studied, and atrophy [3],[4] of this region has clinical consequence; both potential and real. [6],[7],[8] It is the earliest and most severely affected structure in several neuropsychiatric disorders such as Alzheimer's disease (AD), epilepsy etc. [9]

Limbic system is considered to be a "primitive brain," [1] deep with-in brain. It is concerned with hunger, motivation, sex drive, mood, pain, pleasure, appetite, and memory etc. Hippocampus is the posterior part of limbic lobe while frontal part is amygdala. In adult humans, the volume of the hippocampus on each side of the brain is about 3-3.5 cm 3 as compared to 320-420 cm 3 for the volume of the neocortex. [1] Thus, hippocampus is 100 times smaller in volume compared to cerebral cortex.

Papez (1930) proposed that emotional response is organized in hippocampus and is expressed in cingulate gyrus via mammillary bodies. [2] It has also been now implicated in recollecting the past experience and imagining future. [10] Additionally though, known to play a major role in learning, memory and spatial navigation studies also indicate that this is increasingly emerging as a part of 'moral brain.' [11]

   Hippocampal Anatomy Top

Hippocampus contains two parts: Cornu ammonis (hippocampus proper) and dentate gyrus. Both of these parts are separated by hippocampal sulcus and curve into each other. Below the sulcus lies subiculum. Since hippocampus is a part of allocortex (archicortex), there is a zone that separates it from neocortex. Some anatomists divide it into hippocampus proper (Cornu ammonis; CA), dentate gyrus (DG), subiculum, and entorhinal area (EC). Entire set is called as hippocampal formation.

Hippocampus is divided into head, body, and tail; head being expanded part while tail is a thin curved part [Figure 1]. Based upon histology, hippocampus proper (Cornu ammonis) is divided into CA1, CA2, CA3, and CA4 [Figure 2] and [Figure 3]. Just opposite CA1, subiculum is located that connects hippocampus with entorhinal cortex in the ventricle; hippocampus is covered by choroid plexus. Hippocampus is supplied by posterior cerebral artery, which has three branches: Anterior, middle, and posterior. Supply is also reinforced by anterior choroidal artery (uncal branch). Veins of hippocampus drain into basal vein.
Figure 2: Microstructure of hippocampus. Note that this C-shaped structure has been divided into distinct histological domains, and it is now possible to radiologically demarcate CA1, which is the dominant histological region of hippocampus (Figure: courtesy AITBS publishers India)

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Figure 3: Coruna Ammonia. After the Greek God who had horn and this folded structure resembles to that of hippocampal layers. Historically, it has been linked to silkworm or sea horse. A Danish Anatomist divided it into Cornu ammonis, also in short called CA (Figure: courtesy AITBS publishers India)

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Functionally, anatomically, and cytoarchitecturally, hippocampus is quite different from cerebral cortex. For example: Hippocampus is a part of archicortex while cerebral cortex is a part of neocortex. Cortex is outermost structure while hippocampus is a small extension of brain; 5 centimeters in length lying in floor of lateral ventricle. Outer structure of cerebral cortex is highly folded by gyri and sulci while upper surface of hippocampus is convex (which include dentate gyrus, subiculum, and entorhinal cortex). Anterior surface is expanded to form a paw-like structure called pes hippocampi. Importantly, hippocampus is a three-layered structure made up of single pyramidal layer with plexiform layer on both sides.

Hippocampus is an ancient structure in brain that differs both anatomically and physiologically from cerebral cortex. Different cells are organized in layers hippocampus and thus has most extensively been studied part of brain for neurophysiology. Neural substrate of memory, also known as long term potentiation (LTP), was first discovered in this region.

Hippocampus has connections both to and fro from various parts of brain [2],[12],[13],[14] :

  1. Entorhinal Cortex [15] : It has been observed that entorhinal cortex input to dentate gyrus (layer II of perforant path) plays an important role in pattern recognition and encoding of memories.
  2. Perforant Path: Axons present in perforant path arise in layer II and III of entorhinal cortex with little contribution from deeper layers IV and V. Axons of layer II and IV project to granule cells and pyramidal cells of CA3 while those from III and IV project to pyramidal cells of CA1 and subiculum. Importantly, retrieval of information is achieved by entorhinal cortex input to CA3 (layer III of perforant path). A distinct pathway also goes from entorhinal cortex (layer III of perforant path) to CA1 neurons. Pyramidal cells of CA1 send their axons to the subiculum and deep layers of the entorhinal cortex. Subicular neurons send their axons mainly to the EC. Perforant pathway is noteworthy for severe degeneration seen in patients with AD. [12]

    Shaffer's Collaterals: These are axon collaterals given off by CA3 cells of hippocampus coruna and project to CA1 region. Apart from being important part of hippocampal tri-synaptic loop; this part plays an important role in memory formation and also in emotional network of Papez circuit. Conduction in these circuits is excitatory (glutaminergic), and these are involved in activity-dependent neuronal plasticity.
  3. Recurrent Collaterals: These send excitatory input to CA3 and are called recurrent collaterals (RC). These play a vital role in "holding memory." For example, if someone is teaching students and a phone bell rings then CA3 region will remember the information that one was giving to the students temporarily, and this is the function of collaterals.
  4. Dentate Gyrus [16] : It is a deep region within hippocampus and is surrounded by cornu ammonis (CAs). This plays a crucial role as a processor of information from EC to CA3. Cells lying in DG are discharging at a low frequency and provide low intensity stimulation of CA3, which is believed to be an economical storage process. It has been shown to play an important role in pattern separation and associate memory. [16]

Cornu Ammonis (CA1, CA2, CA3, CA4): CA1 contains pyramidal cells principally, and it plays an important role in matching and mismatching of information obtained from CA3. CA2 is a small area and is not considered to be very important hippocampal subfield, except for its high resistance to hippocampal sclerosis due to epileptic damage. Pyramidal cells are also seen in dentate gyrus of hippomcampus. [16]

   Hippocampal Physiology Top

Since hippocampus receives direct inputs from olfactory bulb, it is important that it was implicated in olfaction for a long time. [18] Memory started dominating in early 1970s, with the description of LTP. [19] Anterograde and partial retrograde amnesia developed in a patient called Henry Gustav Molaison (called HM) [20] following removal of hippocampus due to refractory epilepsy. HM was unable to form new episodic memories following this surgery. In medical science, HM has been perhaps the most studied medical patient. Later studies have shown that damage to hippocampus causes anterograde amnesia and often retrograde amnesia also. Implicit memory is spared in hippocampal damage. [20],[21]

Hippocampus is one of the unique regions in brain where the neurogenesis [22] continues even in adult life. Though, described initially, as "too little," neurogenesis in brain is now thought to be functionally important. It has been seen that neurons, hence, produced integrate into the mainstream neurons. They have also, hence, shown to be functionally important. However, a recent review agreed that neurogenesis per se may be less attractive drug target [8] than hippocampal atrophy as a whole.

Hippocampus is now known not just to be important in learning and memory but also in:

  1. Spatial navigation [24]
  2. Emotional behavior [25]
  3. Regulation of hypothalamic functions [27]

  1. Learning and Memory: Hippocampus is vital for learning, memory, and spatial navigation. Connections between hippocampus and neocortex are important for awareness about conscious knowledge. [28] An intricate balance is maintained during encoding of memories in hippocampus and retrieval of experiences from frontal lobe. For learning and memory loop, there are two prominent pathways: polysynaptic and direct pathway. In polysynaptic pathway, hippocampus gets afferent connections from parietal, temporal, and occipital areas via entorhinal cortex and then to dentate gyrus→CA3→ CA1→ subiculum→ alveus→ fimbria→ fornix→ mammillothalamic tract→ anterior thalamus→ posterior cingulated→ retrosplenial cortex. In the direct intra-hippocampal pathway, it gets its input from temporal association cortex through perirhinal and entorhinal area to CA1. From there, projections move via subiculum and entorhinal crtex to inferior temporal cortex, temporal pole, and prefrontal cortex. It is important to remember that polysynaptic pathway is important in semantic memory while direct intra-hippocampal pathway is important in episodic and spatial memory.[28]
  2. Other Roles: Hippocampus is a part of ventral striatal loop, hence can affect motor behavior. [30] Though emotional behavior is regulated mainly by amygdala, hippocampus and amygdala both have reciprocal connections, thus can influence each other (latter affects more than former). Since hippocampus has projections to hypothalamus, thus can affect release of adrenocorticotropic hormones. That is why, in patients with atrophied hippocampus, there is rise of cortisol. [27]

   Hippocampal Pharmacology Top

Hippocampus receives projections that contain serotonin, norepinephrine, and dopaminergic neurons. [30] An important projection, cholinergic and GABAergic in nature, comes from medial septal area and innervates all parts of hippocampus. [31] This projection may play a special role in maintaining physiological state, and destruction of this projection can disrupt hippocampal theta rhythm leading to severe impairment of memory. [32] Entorhinal area [33] plays an important role in visual recognition of objects. Complete amnesia occurs when both hippocampus and entorhinal area are destroyed. Complete amnesia may occur with bilateral hippocampal destruction. However, memory may be preserved with unilateral damage (e.g., stroke) or with hippocampal resection (e.g., temporal lobectomy for epilepsy). Granule cells of dentate gyrus are principally excitatory and contain glutaminergic projections. Some cells also show projections that are immune-reactive for opiates such as dynorphin and endorphins. These have opposing effects on neuronal excitability. [34]

Hippocampal n-methyl d-aspartate receptors [35] have been long known important in learning, memory, and spatial navigation. These are also vitally important in LTP in hippocampus. [36] Similarly, glucocorticoids and mineralocorticoid receptors have assumed important role of late due to description of stress and its role in hippocampal atrophy. [5]

Hippocampus is richly innervated with muscarinic and nicotinic receptors of acetylcholine. [31] Medial septal nucleus is major source of cholinergic output to hippocampus. It represents a direct input both to principle neurons and inter-neurons. Other than this projection, some sparse cholinergic projections are also there. Activity of septo-hippocampal projection [37] has been considered important in hippocampal pacemaker function and also in generating hippocampal theta rhythm. Muscarininc M1 and M3 receptors are expressed in principal cells while M2 and M4 are present on inter-neurons. Nicotinic receptors are also activated by septo-hippocampal pathways. [37] Acetylcholine classically activates pyramidal cells tonically. [31]

Adenosine, [38] via activation of inhibitory A1 receptors, contributes to neuro-modulatory influence. Similarly, by activating A2 A receptors, adenosine [39] can facilitate excitatory neurotransmitter system.

Two different types of GABAergic mechanisms have [40] been identified in hippocampus: Tonic nd phasic. Though in general GABA is an inhibitory neurotransmitter in brain, its role in hippocampus remains to be fully known. Recent reports are appearing that GABA A subunits plays an important role in learning and memory; core functions of hippocampus. GABA receptors are present on principle cells (pyramidal cells) of hippocampus and are important in neural connections between inter-neuronal circuits.

   Patho-Physiology Top

Entorhinal cortex acts as an interface between hippocampus and cerebral cortex. [41] It gives major input to hippocampus via its superficial layers and receives output from deeper layers [Figure 4]. Once the connections leave entorhinal cortex, [42] they go to prefrontal area and lateral septal area.
Figure 4: Basic pathways of hippocampus.[1] Note that entorhinal cortex (EC) sends projections to dentate gyrus, which in turn sends to CA3. Fibers go from here to CA1 region and are called as Schaffers collaterals (SC). Note that, as Mann and Eichenbaum (2005) have suggested, hippocampus operates in the form of a tricynaptic loop. That means, fibers go from EC to DG (1), CA3 to CA1 (2), and from CA1 to subiculum (3), which project to EC again. Lesion or damage to any component along the trisynaptic loop may result into hippocampal dysfunction. Flow of hippocampus is largely unidirectional, and it flows from EC to dentate gyrus and then to CA3 and onwards to CA1. Importantly, main input to hippocampus is from entorhinal cortex, which receives inputs from multiple cortical areas and all sensory modalities.[1] Cortical input that terminates on the layer I, II, III of entorhinal cortex goes to hippocampus.[1] Eventually, this information goes to entorhinal cortex and then to subiculum. It is important to know that each layer of CA has its own complex circuitry and longitudinal connections (Figure: courtesy AITBS publishers India)

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Hippocampal neurons generate a characteristic theta rhythm [43] that has a slow frequency. Perhaps, it is generated by a small group of pyramidal cells. Perhaps, due to its densely packed structure of neurons, hippocampus generates some of the biggest waves in EEG of any brain structure. Most popular hypothesis explaining relevance of these waves suggests that these are related to learning and memory.

It has been seen that the earliest sites of tau deposition [44] and MRI-based atrophic changes typically lie along the perforant pathway. [9] This phenomenon is consistent with early memory deficits in some neurodegenerative diseases such as AD. [45] Consistent with early damage and loss of synaptic density, high resolution MRI-based hippocampal volumetric analysis (T1 weighted) documenting atrophy of this region is the best known and validated marker of AD. [5] It has been seen that despite its convoluted structure, this region can easily be demarcated anatomically than its adjoining regions such as EC and amydala. [9] As a result of disruption produced locally in hippocampus, cholinergic neurons degenerate followed by loss of cholinergic projections from basal forebrain. Cholineacetyl-transferase activity is preserved until late in disease.

   Hippocampal Atrophy Top

Ever since, HM developed severe anterograde amnesia following his surgery; hippocampus has been linked with memory. It is particularly vulnerable to stress and contains rich number of glucocoritcoids, estrogen, and progesterone receptors. A number of mechanisms have been linked to hippocampal atrophy. [8]

Rates of hippocampal atrophy [45] have been used as both diagnostic and prognostic marker in clinical trials of AD. It has been seen that patients with minimal cognitive impairment (MCI), have 10-15% of volume loss of hippocampus while those with early AD, this loss is about 15-30%. [9] In those with moderate AD, it may reach to the extent of 50%. [8]

Although we do not know why hippocampus is so very vulnerable [Figure 5] and undergoes atrophy in diverse conditions, a number of neurochemical and vascular alternations have been identified contributing to hippocampal atrophy. [3] These include glucocorticoids, serotonin, excitatory amino acid, e.g. glutamate and its transporters etc. Importantly, several drugs of unrelated pharmacological classes have been shown to prevent this atrophy implying multi-model manner in which atrophy is produced. [3],[4],[5],[6]
Figure 5: MRI scans showing hippocampal atrophy of both sides in an-85-year-old female with advanced AD

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One of the clear yet not complete mechanisms described for hippocampal atrophy is stress-induced hippocampal atrophy. Circulating glucocortioids are involved in the mechanism that produces atrophy, along with excitatory amino acids (EAA) and serotonin. [1] Atrophy in Cushing's disease and during normal aging involve the entire hippocampal formation and are linked to deficits in short-term verbal memory. [2] This suggests that hippocampal atrophy may have functional consequences as well.

Deposition of neuritic plaques and neurofibrillary tangles appear to be an obvious mechanism. Some regions of hippocampus (e.g. CA1) are particularly vulnerable to global ischemia. Vascular damage leading to capillary abnormalities, neuronal necrosis, microglia, and macrophage formation could also potentially contribute. [5]

Alternation in hippocampal networks has been reported in chronic stress. [5],[8] Similar alterations as started have been reported in Cushing's disease, and also following corticosterone administration. [46] Smaller dendritic spines of hippocampal CA3 regions have been detected following chronic mild unpredictable stress, corticosterone administration, and after chronic stress. [47] Reduced synaptic density in dentate gyrus has been observed following chronic mild stress and also following corticosterone administration in experimental animals. [48] Such a similarity has also been noted in postmortem analysis of brains of patients with AD as well. This may well indicate that hippocampal pathology following stress may resemble to that of case of AD as well. [49] Postmortem analysis of brains of patients with AD have shown reduced number of synapses, both in CA1 region of hippocampus proper and also that in dentate gyrus. [50]

Here are some of the potential mechanisms of hippocampus atrophy:

  1. Deposition of Abeta: Deposition of beta amyloid has been shown to affect spine density and produce more lesions typical of AD. These oligomers have been shown to attach specifically to dendrities implying some causal role of A beta there. [51] Exposure of hippocampal slices to A beta has been shown to produce dendritic atrophy. Decreased dendritic synapse density may lead to loss of excitatory synapses. In transgenic mice, immunotherapy against A beta has been shown to reduce synaptic degeneration. Basal glucocorticoids produced in AD may be responsible reducing dendritic spines and synapse. [52]
  2. Suppression of Hippocampal Neurogenesis: It could be induced by glucocorticoids administration and/or by chronic stress. [53],[54] Neurogenesis in hippocampus is perhaps a mechanism of exhibiting responses to external environment. [55] Exact role played by hippocampal neurogenesis in memory is not known. However, if neurogenesis is suppressed, then spatial and contextual memory is impaired in experimental animals. [53] Therefore, atrophied hippocampus can actually be due to a combination of cell loss and suppression of neurogenesis. [55]
  3. Impairment of Long-Term Potentiation: Enhancement of postsynaptic potentials following presynaptic stimulation is widely believed to be neural substrate of learning and memory. [30] Chronic stress, glucorticoid administration has been shown to disrupt long-term potentiation and induce long term depression. [56] Impairment of LTP has been shown to occur early in experimental animals, much before significant amyloid deposition occurs in hippocampus. Exposure to A beta can cause impairment of LTP in animals [57] and is resolved by using anti-A beta immunotherapy. [58] Infusion A beta in rats can induce impairment of LTP, [59] and this is exacerbated by mild chronic stress.
  4. Oxidative Stress [60] Increase formation of oxygen-derived free radicals leading to lipid peroxidation in brain is seen in AD patients. Abeta [57],[58] and stress [56] both can increase production of free radicals in brains of experimental animals.
  5. Metabolic Stress: Impairment of energy metabolism has been demonstrated in early AD. Similarly, mitochondrial deficits have been seen in both, in mild cognitive impairment or in those with AD. Stress has been shown to impair glucose transport in neurons. Whether these represent cause or consequence of Alzheimer's is not clear.

Neurotropic Factors: One of the adaptive response to mild stress in brain is to increase cyclic AMP response element-binding protein expression that will eventually code for neurotropic factors. [61] Severe stress or corticosterone administration can impair neurotropic factor production. [62] Brain derived neurotropic factor (BDNF) production can get reduced in both, in hippocampaus and also in entorhinal cortex in AD brain. [63] Since BDNF regulates neural network and protects hippocampal neurons against oxidative, metabolic and excitotoxic stress, [64] its malfunction or reduced production will have deleterious consequences. Both stress and ageing have consistently been shown to reduce levels of BDNF and thus increasing vulnerability of brain to damage. [65]

Serotonin released by stress or corticosterone may interact pre- or post-synaptically with glutamate released by stress or corticosterone, and the final common path may involve interactive effects between serotonin and glutamate receptors on the dendrites of CA3 neurons innervated by mossy fibers from the dentate gyrus. [2] Chronic restraint stress increases glutamate transporters (e.g. GLT-1) mRNA expression in the dentate gyrus and CA3 region of Ammon's horn, increases that are inhibited by a selective serotonin reuptake enhancer (SSRE) e.g. tianeptine. [3]

These transporters have also been shown to be inhibited by lithium, [4] which additionally reduces CREB (cAMP response binding element) expression. It has been suggested that these effects may be important in preventing the glutaminergic contributing to hippocampal atrophy seen in major depression and bipolar disorders. Nitric oxide synthetase activation can also bring about dendritic atrophy, which is prevented by fluoxetine, a commonly used SSRI. [5] This enzyme brings about morphological abnormalities in a localized area of the brain. Thus, based upon current pharmacological evidences, it appears that hippocampal atrophy develops as a result of interplay between glucocorticoids, serotonin, and excitatory amino acids. [4],[5]

The following are some of the common conditions in which atrophy of human hippocampus has been reported:

Alzheimer's disease [5],[6],[8],[66]

Atrophy of hippocampal region in brains is one of the most consistent features of AD. It is the earliest brain region and is most severely affected. A popular hypothesis called 'hippocampo-cortical-dissociation' has proposed that early damage to hippocampus causes a 'dissociation' between hippocampus and cerebral cortex, leading to failure of registration of information emanating from hippocampus. Some amount of hippocampal atrophy is seen in all patients with AD. [8] A number of neurotransmitter alterations also occur in brains of AD such as noradrenergic, serotonergic, and glutaminergic regions corresponding to neuron loss in hippocampal region.

Depression [5],[6],[68]

Ever since the biological basis of depression is getting unfolded, evidence is accumulating that prolonged depression can cause volume loss of hippocampus. Moreover, duration of depression has been correlated with severity of hippocampal atrophy. Evidence suggests that atrophy thus produced may be permanent and persist long even though depression has undergone remission. It has been hypothesized that it could be a consequence of affective disturbance seen in depression. It is believed that this could result from prolonged stress generated as a result of depression. Retraction of cell volume and/or suppression of hippocampal neurogenesis could be responsible in this case.

"there is a reason to believe that disturbance in hippocampus is responsible for production of psychotic symptoms in schizophrenia"

-Donald R. Robert, 1963

Hippocampal volume reduction is one of the most consistent findings found in MRI of schizophrenic patients. Functional and biochemical abnormalities have also been identified there. Though initially patho-physiology of schizophrenia focused mainly upon prefrontal cortex, but now hippocampus is being considered for last 20 years or so. Now there is compelling data to suggest that there are anatomical and functional aberrations due to neuronal disturbances in hippocampus of schizophrenic patients. Evidence has been gathered from MRI, PET, and MRS studies of disturbances with in hippocampus of schizophrenia. Volume reduction in hippocampus of schizophrenia is modest and not as marked as that seen in AD. Still, biochemical and functional disturbances provide a reliable evidence of involvement of hippocampus in patho-physiology of schizophrenia.

Epilepsy [3],[6],[8]

Up to 50% to 75% of patients with epilepsy may have hippocampal sclerosis upon postmortem analysis, in case they died and had medically refractory temporal lobe epilepsy. It is, however, not clearly known if epilepsy is generated as a result of hippocampal sclerosis or repeated seizures damage hippocampus. That means, it is not yet clear that hippocampal atrophy is a cause or consequence of recurrent seizures. [69],[70] Mechanism of hippocampal sclerosis in epilepsy may be related to development of uncontrolled local hippocampal inflammation and blood brain barrier damage. [70] Cytoskeletal abnormalities, neurotransmitter alterations, and hypoxia caused by recurrent seizures may be additional associated factors. [3],[5],[6],[8] Developing hippocampus may be more susceptible to damage compared to matured one. [69] Recent evidence also suggests that hippocampal sclerosis in epilepsy may be an acquired process with accompanying re-organizational dysplasia and an extension of mesial temporal sclerosis rather than a separate pathological entity. [71] That means significant progress is being made in understanding relationship between hippocampal sclerosis and epilepsy.

It is believed that hippocampus has an inhibitory effect on seizure threshold (i.e. it keeps it elevated). Once it gets damaged, then seizures become more intractable. Surgical resection of the hippocampus is the most successful treatment for medication-refractory medial temporal lobe epilepsy due to hippocampal sclerosis. [72]

We also did a study and found that patients with AD with seizures had hippocampal atrophy. [6] Cause of hippocampal atrophy in epilepsies is not known; autoimmunity has been proposed as one of the mechanism.

Hypertension [3],[6],[8]

Hypertension and other risk factors are now increasingly being viewed as putative factors leading to hippocampal atrophy. Probable reasons include vascular insult leading to ischemia, hypo-perfusion, and hypoxia of neurons. Studies have shown that in many patients with AD, blood pressure is increased decades before onset of AD.

Cushing's Disease [3],[6]

Loss of cellular volume in response to corticosteroids could be responsible here. Dendritic atrophy, leading to shrinkage of cells, may lead to additional volume loss. Suppression of neurogenesis may be an additional feature. Evidence indicates if Cushing's disease is treated, then hippocampal atrophy could be reversible.

Miscellaneous Causes [3],[6],[8]

Head injury and post-traumatic stress disorders are other diseases associated with hippocampal atrophy. Injury, leading to vascular insults, could be mechanism in former while stress hormones such as corticosteroids could be responsible in latter.

   Conclusions Top

Hippocampus is an extension of cerebral cortex situated deep into temporal lobe. It is a vulnerable and plastic structure. It gets damaged by a variety of stimuli, and hence is important clinically both diagnostically and therapeutically. Currently, it is one of the marker of cognitive decline and diagnosis of AD. It is also a prognostic marker in research setting. Drugs that are able to cause slow down of atrophy or reversal are actively being sought. These could then potentially have disease-modifying effects.[5],[23],[26],[29],[67]

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57 Probing the molecular and cellular pathological mechanisms of schizophrenia using human induced pluripotent stem cell models
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63 Differential Regulation of Mouse Hippocampal Gene Expression Sex Differences by Chromosomal Content and Gonadal Sex
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64 The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease
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69 Defects of parvalbumin-positive interneurons in the ventral dentate gyrus region are implicated depression-like behavior in mice
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70 The impact of obesity-related neuroinflammation on postpartum depression: A narrative review
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71 Short-term effects of therapeutic hypothermia following hypoxia–ischemia in neonatal male and female rats
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72 Volumetric differences in hippocampal subfields and associations with clinical measures in myalgic encephalomyelitis/chronic fatigue syndrome
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74 Hippocampus Segmentation Using U-Net Convolutional Network from Brain Magnetic Resonance Imaging (MRI)
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75 Therapeutic hypothermia for the treatment of neonatal hypoxia-ischemia: sex-dependent modulation of reactive astrogliosis
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77 The effects of bilingualism on hippocampal volume in ageing bilinguals
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78 The Role of Blood–Brain Barrier Dysfunction in Mild Cognitive Impairment: a Scientometric and Visualization Analysis from 2000 to 2021
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79 NADPH Oxidase: a Possible Therapeutic Target for Cognitive Impairment in Experimental Cerebral Malaria
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80 Diagnosis of Alzheimer disease in MR brain images using optimization techniques
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81 Deep transfer learning for alzheimer neurological disorder detection
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82 Hepatic Encephalopathy: From Metabolic to Neurodegenerative
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84 Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway
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87 Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid “hesperidin”
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88 Human CALHM5: Insight in large pore lipid gating ATP channel and associated neurological pathologies
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89 Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex
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90 Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions
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91 Involvement of the ventral, but not dorsal, hippocampus in anxiety-like behaviors in mice exposed to the elevated plus maze: participation of CRF1 receptor and PKA pathway
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92 Neuroprotective and acetylcholinesterase inhibitory activity of plumbagin in ICV-LPS induced behavioral deficits in rats
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93 A deep learning framework with an embedded-based feature selection approach for the early detection of the Alzheimer's disease
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94 Pachypodol protects newborn rats from anaesthesia-induced apoptosis in the developing brain by regulating the JNK/ERK pathway
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95 Effects of sub-chronic caffeine ingestion on memory and the hippocampal Akt, GSK-3ß and ERK signaling in mice
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96 Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies
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97 Fatal coccidioidomycosis involving the lungs, brain, tongue, and adrenals in a cirrhotic patient. An autopsy case
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98 Therapeutic potential of ketamine for alcohol use disorder
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99 Adult brain cytogenesis in the context of mood disorders: From neurogenesis to the emergent role of gliogenesis
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100 Neurobehavioral effects of acute low-dose whole-body irradiation
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101 Changes in brain MRI under different lunar cycles: a cross-sectional study
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102 Maternal pineal melatonin in gestation and lactation physiology, and in fetal development and programming
Patrícia Rodrigues Lourenço Gomes, Lívia Clemente Motta-Teixeira, Camila Congentino Gallo, Daniella do Carmo Buonfiglio, Ludmilla Scodeler de Camargo, Telma Quintela, Russel J. Reiter, Fernanda Gaspar do Amaral, José Cipolla-Neto
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103 Hippocampal Segmentation in Brain MRI Images Using Machine Learning Methods: A Survey
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104 Preschool physical activity and fitness predicts conceptual, verbal and perceptual skills at school
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105 Combinatorial analyses reveal cellular composition changes have different impacts on transcriptomic changes of cell type specific genes in Alzheimer’s Disease
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106 The Critical Role of Hippocampal Dopamine in the Pathogenesis of Hepatic Encephalopathy
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107 Objectively Measured Intensity-specific Physical Activity and Hippocampal Volume Among Community-dwelling Older Adults
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108 Intranasal Photobiomodulation Therapy for Brain Conditions: A Review
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109 A Focus on the Reminiscence Bump to Personalize Music Playlists for Dementia
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110 Neuroprotective Effect of Fucoxanthin against Intracerebroventricular Streptozotocin (ICV-STZ) Induced Cognitive Impairment in Experimental Rats
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111 Complex Posttraumatic Stress Disorder and Rehabilitation Counseling
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112 Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update
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113 Silver Nanoparticles Conjugate Attenuates Highly Active Antiretroviral Therapy-Induced Hippocampal Nissl Substance and Cognitive Deficits in Diabetic Rats
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114 Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases
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115 Influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats
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116 The hollow: A theory on workplace bullying in nursing practice
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117 Limbic Encephalitis Associated with COVID-19
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118 Domestication and Feed Restriction Programming Organ Index, Dopamine, and Hippocampal Transcriptome Profile in Chickens
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119 Melatonin Protects against the Side-Effects of 5-Fluorouracil on Hippocampal Neurogenesis and Ameliorates Antioxidant Activity in an Adult Rat Hippocampus and Prefrontal Cortex
Kornrawee Suwannakot, Nataya Sritawan, Ram Prajit, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
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120 Classification of Alzheimer’s Disease Patients Using Texture Analysis and Machine Learning
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121 Alcohol Induced Brain and Liver Damage: Advantages of a Porcine Alcohol Use Disorder Model
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122 Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model
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Frontiers in Neurology. 2021; 12
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123 The Hippocampal Vulnerability to Herpes Simplex Virus Type I Infection: Relevance to Alzheimer’s Disease and Memory Impairment
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124 Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer’s Disease
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125 Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders
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126 Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response
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127 Physical Activity, Fitness, and Cognitive Performance of Estonian First-Grade Schoolchildren According Their MVPA Level in Kindergarten: A Longitudinal Study
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128 Isolation, Characterization and Neuroprotective Activity of Folecitin: An In Vivo Study
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129 Kir4.1 Dysfunction in the Pathophysiology of Depression: A Systematic Review
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130 Neuronal Menin Overexpression Rescues Learning and Memory Phenotype in CA1-Specific a7 nAChRs KD Mice
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131 Human neural progenitor cells ameliorate NMDA-induced hippocampal degeneration and related functional deficits
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132 Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene
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133 Current understanding of glucose transporter 4 expression and functional mechanisms
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134 Prospects for microbiota-oriented therapy in neurorehabilitology
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135 Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms
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Frontiers in Neuroscience. 2020; 14
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136 Neural Signatures of Learning Novel Object–Scene Associations
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137 Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet
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138 Angelman syndrome: a journey through the brain
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139 Exercise Interventions as the Primary Treatment for Depression: Evidence from a Narrative Review
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140 Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review
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141 Mitochondrial Fusion Promoter Alleviates Brain Damage in Rats with Cardiac Ischemia/Reperfusion Injury
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