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Year : 2012  |  Volume : 15  |  Issue : 4  |  Page : 344-346

An Indian family with an Emery-Dreifuss myopathy and familial dilated cardiomyopathy due to a novel LMNA mutation

Department of Neurology, Lourdes Heart Institute and Neuro Center, Kochi, Kerala, India

Date of Submission12-Dec-2011
Date of Decision11-Jan-2012
Date of Acceptance23-Jun-2012
Date of Web Publication5-Dec-2012

Correspondence Address:
Boby V Maramattom
Department of Neurology, Lourdes Hospital, Kochi-682012, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.104355

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Emery-Dreifuss myopathy can be associated with a cardiomyopathy and cardiac dysrhythmias. The inheritance pattern of Emery-Dreifuss muscular dystrophy (EDMD) is X linked, whereas EDMD2 is autosomal dominant. EDMD2 is caused by lamin A/C gene (LMNA) mutations that produce alterations in the lamin proteins that are integral to nuclear and cell integrity. A 53-year-old man was brought to us with a right internal carotid artery dissection. Detailed work-up of the patient and family members revealed some unusual features, and genetic sequencing of the LMNA gene was undertaken. A novel mutation was identified in two of the samples sent for analysis. We present the first Indian family of EDMD2 with familial dilated cardiomyopathy and cardiac dysrhythmias in whom LMNA gene sequencing was performed. A novel mutation was identified and additional unusual clinical features were described.

Keywords: Calcified AV node, cardiac conduction system calcification, cardiomyopathy, EDMD, familial DCM, LMNA mutation, myopathy

How to cite this article:
Jadhav KB, Karpe KK, Maramattom BV. An Indian family with an Emery-Dreifuss myopathy and familial dilated cardiomyopathy due to a novel LMNA mutation. Ann Indian Acad Neurol 2012;15:344-6

How to cite this URL:
Jadhav KB, Karpe KK, Maramattom BV. An Indian family with an Emery-Dreifuss myopathy and familial dilated cardiomyopathy due to a novel LMNA mutation. Ann Indian Acad Neurol [serial online] 2012 [cited 2023 Jan 30];15:344-6. Available from:

   Introduction Top

 Emery-Dreifuss muscular dystrophy More Details (EDMD) and limb-girdle muscular dystrophy type 1B (LGMD1B) are similar muscular dystrophies associated with cardiac arrhythmias and cardiomyopathy. Inheritance is X-linked recessive when the emerin gene is mutated, resulting in EDMD or autosomal dominant when the lamin A/C gene (LMNA mutation) is mutated, resulting in EDMD2 or LGMD1B. [1] LMNA mutation carriers present at an early age with features of skeletal myopathy, cardiac dysrhythmias or cardiomyopathy. The clinical course can also be punctuated by ventricular tachycardia or sudden cardiac death. Numerous mutations have been identified in the LMNA gene. [2] Until now, genetic sequencing of LMNA mutations in Indian families has not been described. We describe the first large Indian family with a combination of Emery-Dreifuss myopathy, familial dilated cardiomyopathy (FDCM) and cardiac conduction abnormalities due to a novel LMNA mutation.

   Case Report Top

A 53-year-old man was admitted to the neurology intensive care unit with an acute ischemic stroke of 2 h duration. On examination, he had a dense right hemiplegia and global aphasia. Computed tomography (CT) brain was normal. He was started on IV thrombolysis with 20 mg of Recombinant Tissue Plasminogen Activator (rtPA) and taken up for intra-arterial thrombolysis. Four-vessel digital subtraction angiography (DSA) revealed a left internal carotid artery (ICA) dissection with flame-shaped occlusion at the carotid bifurcation. Despite multiple attempts, the artery could not be recanalized and the procedure was abandoned. He remained densely hemiplegic and aphasic after the procedure. On detailed questioning, his brother revealed that 10 members of his extended family had undergone cardiac permanent pacemaker implantations (PPI) in the past 15 years [Figure 1]. The youngest brother of the proband had developed difficulty in walking and had been diagnosed with a possible myopathy or spinal muscular atrophy 5 years earlier. He had undergone a PPI 2 years earlier. Another cousin reported a stiff back and had restricted spinal flexion as well as a mild myopathy and a PPI. The possibility of a familial cardiac conduction defect with skeletal myopathy was considered and further detailed evaluation was undertaken. Further evaluation of the proband revealed wasting of the shoulder girdle, enlarged forearms (Popeye forearms), wasting of the peroneal muscles and high arched feet [Figure 2]. Examination of his sibling with the myopathy and the cousin with a stiff back showed the same muscular phenotype. Echocardiogram showed a dilated left ventricle with an ejection fraction of 39%, suggesting a dilated cardiomyopathy (DCM). A CT chest revealed calcification of the A-V node as well as the proximal bundle of His [Figure 3]. Ultrasound abdomen revealed small liver (8 cm) with coarse echotexture, portal vein dilatation and mild splenomegaly (suggestive of cirrhosis). Three weeks after admission, the patient developed massive hematemesis and expired. After discussion with the family and obtaining informed consent, blood was sampled from the patient as well as from a first cousin and dispatched to Diagenos Lab (Germany) for genetic sequencing. The entire coding region of the LMNA gene was sequenced by polymerase chain reaction (PCR). PCR products were analyzed by direct sequencing. This revealed a heretofore undescribed heterozygous mutation in the LMNA gene: c.1059_1060 delGC insCT (p.[Gln353His];[Gln354Term]). This mutation resulted in two amino acid changes. The amino acid change p.Gln354Termn resulted in a premature termination signal.
Figure 1: Family pedigree

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Figure 2: Panel A shows wasting of the shoulder girdle and prominent/hypertrophic forearm muscles (Popeye forearms). Panel B shows preservation of the thigh muscles, wasting of the peroneal muscles and high arched feet

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Figure 3: Anterior arrow shows the pacemaker lead in situ. Posterior arrow shows the A-V nodal and proximal bundle of His calcification on plain computed tomography thorax reconstructed images

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   Discussion Top

The family that we have described had an autosomal-dominant familial cardiac dysrhythmia appearing in the 4 th -5 th decades of life and skeletal myopathy with humero-peroneal preponderance and stiff back with reduced spinal flexion. Other unusual features included cardiac conduction system calcification, cirrhosis. A stiff back can be associated with rigid spine syndrome (SEPN1 mutations), Bethlem myopathy and Ullrich congenital muscular dystrophy, which are allelic disorders caused by collagen VI gene mutations, EDMD 2 (LMNA mutations) or calpain-deficient LGMD (CAPN3 mutations). [3] Two patients in this family also had a DCM. This last feature helped classify the disorder as a FDCM. [4] EDMD is usually characterized by elbow/ankle contractures, muscular dystrophy and cardiomyopathy. Clinically, the combination of autosomal-dominant inheritance, humero-peroneal predominant skeletal myopathy, stiff back with limited spinal flexion and a familial DCM suggested the diagnosis of EDMD2. Hence, we proceeded with genetic sequencing of the LMNA gene.

The LMNA gene or the LMNA gene is located on chromosome 1q 21-22. It encodes the lamin proteins that form part of the nuclear lamina. The lamin proteins (isoforms A and C) are important in chromatin structure and nuclear stability, and are composed of intermediate filament proteins, which provide scaffolding to the nuclear envelope and are located in the nuclear lamina, a layer that is attached to the inner membrane of the nuclear envelope. The lamin proteins interact with a variety of proteins, including lamin B receptors, lamin-associated polypeptides and emerin. However, the process by which these mutations result in different phenotypes is unknown, although it is postulated that apoptosis in the cardiac conduction system may lead to the conduction abnormalities. [5] Mutations in the LMNA gene are associated with several diseases, including EDMD, LGMD type I B, dilated cardiomyopathy with conduction abnormalities, autosomal-recessive  Charcot-Marie-Tooth disease More Details type 2 (CMT2B1), familial partial lipodystrophy of the Dunnigan-type (FPLD), mandibuloacral dysplasia (MAD) and Progeria syndrome.

Cardiac dysrhythmias in familial DCM tend to occur along a continuum. Sinus bradycardia as a result of SA nodal dysfunction is seen in the early stages, followed by atrial arrhythmias and atrial myopathy. Subsequently, A-V nodal dysfunction sets in, followed by LV dysfunction (ventricular myopathy). Sudden cardiac death can occur at any time, as was seen in our family also. Hence, the importance of identification of an LMNA mutation is that it should trigger consideration of a pacemaker with an implantable cardioverter-defibrillator (ICD) rather than an ordinary pacemaker as all our patients were subjected to.

Calcification of the cardiac conduction system is unusual and is seen only in a few conditions such as Lev's disease, calcific aortic stenosis, mitral annular calcification or, rarely, in chronic hemodialysis patients with metastatic calcification. [6] Familial DCM has not yet been reported with AV node or bundle of His calcification.

Steatosis has been described in one case of lipoatrophy due to LMNA mutations, but cirrhosis is hitherto undescribed. [7] Our family is the first reported association of cirrhosis with LMNA mutation. Unfortunately, the type and cause of cirrhosis in this family could not be elucidated further as liver biopsy could not be performed.

In conclusion, this is the first documented Indian family with an Emery-Dreifuss myopathy, familial DCM, calcification of the cardiac conduction system and cirrhosis due to a novel LMNA mutation.

   References Top

1.Saga A, Karibe A, Otomo J, Iwabuchi K, Takahashi T, Kanno H, et al.. Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia. Tohoku J Exp Med 2009;218:309-16.  Back to cited text no. 1
2.Parks SB, Kushner JD, Nauman D, Burgess D, Ludwigsen S, Peterson A, et al. Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. Am Heart J 2008;156:161-9.  Back to cited text no. 2
3.Mercuri E, Clements E, Offiah A, Pichiecchio A, Vasco G, Bianco F, et al. Muscle magnetic resonance imaging involvement in muscular dystrophies with rigidity of the spine. Ann Neurol 2010;67:201-8.  Back to cited text no. 3
4.Mestroni L, Maisch B, McKenna WJ, Schwartz K, Charron P, Rocco C, et al. Guidelines for the study of familial dilated cardiomyopathies. Collaborative Research Group of the European Human and Capital Mobility Project on Familial Dilated Cardiomyopathy. Eur Heart J 1999;20:93-102.  Back to cited text no. 4
5.Malhotra R, Mason PK. Lamin A/C deficiency as a cause of familial dilated cardiomyopathy. Curr Opin Cardiol 2009;24:203-8.   Back to cited text no. 5
6.Kuzela DC, Huffer WE, Conger JD, Winter SD, Hammond WS. Soft tissue calcification in chronic dialysis patients. Am J Pathol 1977;86:403-24.  Back to cited text no. 6
7.Caux F, Dubosclard E, Lascols O, Buendia B, Chazouillères O, Cohen A, et al. A new clinical condition linked to a novel mutation in lamins A and C with generalized lipoatrophy, insulin-resistant diabetes, disseminated leukomelanodermic papules,liver steatosis, and cardiomyopathy. J Clin Endocrinol Metab 2003;88:1006-13.  Back to cited text no. 7


  [Figure 1], [Figure 2], [Figure 3]

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