Annals of Indian Academy of Neurology
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Year : 2013  |  Volume : 16  |  Issue : 2  |  Page : 276-278

Familial orthostatic tremor and essential tremor in two young brothers: A rare entity

1 Department of Neuromedicine, RG Kar Medical College and Hospital, Kolkata, West Bengal, India
2 Department of Neuromedicine, Calcutta National Medical College, Kolkata, West Bengal, India

Correspondence Address:
Kalyan B Bhattacharyya
Amrapali Point, Flat 1C, 59F, Bosepukur Road, Kolkata - 700 042, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.112497

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Orthostatic tremor (OT), is usually a disease of old age and is characterized by quivering movements of the legs during quiet standing or in the state of isometric contraction in the lower limbs. This is relieved on walking or on lying down. It is diagnosed by surface electromyography, particularly over the quadriceps femoris muscles which shows a distinctive frequency of 13 to 18 Hz on standing. Some investigators consider it as a variant of essential tremor (ET) and the two conditions often co-exist. The disease is usually non-familial. Two brothers presented with tremor in the lower limbs on standing and on the outstretched hands without any family history. Subsequently, they were proved to be suffering from OT and ET by clinical examination and surface EMG. Simultaneous occurrence of OT and ET in two young brothers without any family history in the previous generation has not been described before and they also appeared at a much earlier age than what is described in the literature.

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