|Year : 2013 | Volume
| Issue : 3 | Page : 432-436
Congestive myelopathy (Foix-Alajouanine Syndrome) due to intradural arteriovenous fistula of the filum terminale fed by anterior spinal artery: Case report and review of literature
Prasad Krishnan1, Tapas Kumar Banerjee2, Manash Saha3
1 Department of Neurosurgery, National Neurosciences Centre, Peerless Hospital Complex, IInd Floor, 360 Panchasayar, Kolkata, West Bengal, India
2 Department of Neurology, National Neurosciences Centre, Peerless Hospital Complex, IInd Floor, 360 Panchasayar, Kolkata, West Bengal, India
3 Department of Radiology, National Neurosciences Centre, Peerless Hospital Complex, IInd Floor, 360 Panchasayar, Kolkata, West Bengal, India
|Date of Submission||26-Jan-2013|
|Date of Decision||10-Mar-2013|
|Date of Acceptance||28-Feb-2013|
|Date of Web Publication||26-Aug-2013|
Flat 3B, 9 Southend Park, Kolkata 700 029, West Bengal
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Spinal arteriovenous fistulas are rare entities. They often present with congestive myelopathy but are infrequently diagnosed as the cause of the patients' symptoms. Only one such case has been described previously in Indian literature. We describe one such case who presented to us after a gap of 3 years since symptom onset and following a failed laminectomy where the cause was later diagnosed to be an intradural fistula in the filum terminale fed by the anterior spinal artery and review the available literature.
Keywords: Anterior spinal artery, congestive myelopathy, filum terminale, intradural arteriovenous fistula
|How to cite this article:|
Krishnan P, Banerjee TK, Saha M. Congestive myelopathy (Foix-Alajouanine Syndrome) due to intradural arteriovenous fistula of the filum terminale fed by anterior spinal artery: Case report and review of literature. Ann Indian Acad Neurol 2013;16:432-6
|How to cite this URL:|
Krishnan P, Banerjee TK, Saha M. Congestive myelopathy (Foix-Alajouanine Syndrome) due to intradural arteriovenous fistula of the filum terminale fed by anterior spinal artery: Case report and review of literature. Ann Indian Acad Neurol [serial online] 2013 [cited 2021 Mar 3];16:432-6. Available from: https://www.annalsofian.org/text.asp?2013/16/3/432/116931
| Introduction|| |
Spinal arteriovenous fistulas are rare entities. They may be extradural or intradural. The intradural variants may have feeders from the radicular arteries [called dorsal type] or anterior spinal artery [ventral type]. The artery of the filum terminale is a continuation of the anterior spinal artery and contributed to the fistula formation in our case. The high flow in these fistulas caused intramedullary venous hypertension and the entity of congestive myelopathy.
| Case Report|| |
A 54-year-old male presented with gradually progressive history of walking difficulty, weakness, and decreased sensation in lower limbs, diffuse gluteal, and leg pain and bowel and bladder incontinence of 3 years duration. He had undergone L4-L5 fenestration and microdiscectomy (in another hospital) 2 years previously for a disc bulge that was thought to be the causative pathology. As there was steady deterioration even after this procedure, he underwent nerve conduction studies that were inconclusive and was on various types of medication and physiotherapy. A repeat magnetic resonance imaging (MRI) of the whole spine was now carried out, which showed multiple flow voids in the dorsal sub arachnoid space (from C3 to L4) and T 2 hyperintense signal change in the dorsal cord from D6 body to the conus [Figure 1]. At current presentation, he was unable to stand, even with support. Bilateral foot drop was present. Right lower limb power was grade 3/5 in hip flexors and knee extensors and 2/5 in knee flexors, ankle plantar flexors, and hip extensors. Left lower limb power was grade 4/5 in hip and knee flexors and extensors and 3/5 in ankle plantar flexors. Power in bilateral ankle dorsiflexors, toe flexors, and extensors was grade 0/5. There was wasting of the muscles of the lower limb and foot. Bilateral knee and ankle jerks were absent. All modalities of sensation were decreased from L3 dermatome downwards bilaterally with complete perineal anesthesia.
|Figure 1: Magnetic resonance imaging spine (sagittal view) showing multiple flow voids in the dorsal sub arachnoid space (from C3 to L4) and hyperintense signal change in the dorsal cord from D6 body to the conus|
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Spinal digital subtraction angiography (DSA) showed an arteriovenous fistula (AVF) of the filum terminale at L4 level fed by a single mid-line descending anterior spinal artery (ASA) that was augmented by a radicular feeder from D12 level. A tortuous vein was looping back from L4 and running cranially [Figure 2] and [Figure 3].
|Figure 2: DSA showing an arteriovenous fistula of the filum terminale at L4 level fed by a single midline descending ASA. DSA (lateral view) showing that the arterial feeder (ASA) abutting the posterior cortex of the vertebral body|
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|Figure 3: Anterior spinal artery is augmented by a radicular feeder from left D12 level that takes a hairpin bend as it descends. Digital subtraction angiography showing the arteriovenous fistula of the filum terminale with the enlarged, tortuous vein looping back from L4 and running back cranially|
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The patient underwent L3 laminectomy and disconnection of the AVF by coagulating and cutting the feeding artery and vein after application of separate "Liga" clips proximally and distally on both. Intra operatively, the vein was tortuous and thickened. There was no evidence of any filling of the vein after the artery had been initially disconnected. The arachnoid was clear and thin and had no stigma of prior subarachnoid hemorrhage. The patient had slow recovery of motor and sensory functions and also regained reasonable sphincter control in the following 6 months. His dysesthesias and leg and gluteal pain also disappeared. A repeat MRI done at 5 months follow-up showed disappearance of flow voids as well as cord T 2 hyperintensity [Figure 4]. Currently at 14 months follow-up, he is independently ambulant, continent and has full power in both lower limbs.
|Figure 4: Magnetic resonance imaging done at 5 months follow-up showing disappearance of flow voids as well as cord hyperintensity|
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| Discussion|| |
Congestive myelopathy due to spinal arteriovenous fistulas (AVF's) was first described by Foix and Alajouanine in 1926 who called it necrotizing myelopathy , and subsequently by Lhermitte in 1931.  In 1974 Aminoff and Logue hypothesized that in the presence of an AVF there is increased intramedullary venous pressure with resultant decrease of the arteriovenous pressure gradient and concomitant decrease of cord perfusion. , Irrespective of the location of the fistula it is the lower part of the cord that is affected commonly and shows signal changes on MRI. Two reasons are put forward to this phenomenon- (a) the intraspinal venous system is valveless and due to gravity the lower part of the cord is more congested and (b) the collateral outflow from the lower part of the dorsal cord is less even in normal subjects  and this leads to impaired dissipation of venous hypertension found in patients with AVF's.
This affliction of the lower part of the cord leads to the commonly observed symptoms of dysesthesias, non-dermatomal sensory loss, walking difficulty, wasting, weakness of lower limbs, buttock pain, and sphincter dysfunction. ,,
Often this condition is misdiagnosed as polyradiculopathy, polyneuropathy, intramedullary tumor, etc., and the same has been highlighted by various authors. , Another cause of the misdiagnosis is the rarity of the condition  and has led one study (in the Netherlands) to speculate that a neurologist can expect to see one such case only every 4-8 years.  The result is that 40-63% of patients have disease of 1-3 years duration and 10-34% of patients have disease for greater than 3 years by the time they are diagnosed.  Our patient too gave a history of more than 3 years duration in the course of which he had been subjected to lumbar laminectomy and multiple nerve conduction studies to no avail.
There are several classifications of spinal vascular lesions. Spetzler et al.  grouped them into three major classes [Table 1]. Of these spinal AVF's are further sub classified depending on their vascular supply [Table 2].
Intradural (ventral or perimedullary) AVF's as a separate entity were first described by Djindjian in 1977 , and are said to account for 20% of all spinal vascular malformations.  Filum terminale AVF's is a rare variant , of intradural AVF's. The filum terminale is supplied by a single feeder that is a continuation of the ASA or a branch descending from the "vascular basket "at the conus. , There is no radicular arterial supply as there are no rootlets that exit the filum.  The vein of the filum terminale drains the blood either cranially into the ventral vein of the spinal cord or caudally into the sacrum extra dural plexus. , Hence any AVF below the conus that has supply only from the ASA with no lumbar radicular augmentation can be considered to be a filum terminale AVF.
Rodesch et al. found 3.1% prevalence of filum terminale AVF's in patients with intradural AVF's.  We performed a PubMed search using the terms 'congestive myelopathy' and 'AVF' and retrieved only 29 articles. A search with the terms 'filum terminale' and 'AVF' yielded 28 results. However, after removing cases associated with extradural fistulas, diastematomyelia, schwannomas, hemangioblastomas and aortocaval fistulas, we found only 12 cases of filum terminale AVF's fed by the ASA causing congestive myelopathy [Table 3].
Both surgical and endovascular treatment options are mentioned in literature. Lin et al.  conclude that if there is a large distance from the origin of the artery to the fistula site, clipping would be the safer option than embolization. Others  too have emphasized on the need for a high index of suspicion to establish diagnosis and hold that surgery is safer with decreased risk of spinal cord ischemia as compared to embolization. , Trinh et al.  have also preferred surgery rather than endovascular treatment in their two cases. Witiw et al.  have reported indirect treatment of the AVF by transection of the filum as have Tender et al. in their two cases. 
In our case, the hairpin loop cranially at the point where the radicular artery augmented the ASA precluded any attempt at embolization and hence, surgery was carried out.
All cases described in literature have had a satisfactory recovery. Factors determining prognosis are said to be duration of illness, sphincter involvement at presentation and location of fistula however, there is no consensus on any of these.  Before our case, only one such has been published in Indian literature.  Five of these 12 patients had undergone surgical procedures previously in the lumbar spine before a correct diagnosis was made.
To conclude, diagnosis of congestive myelopathy due to a spinal vascular malformation requires a high index of suspicion. Any patient with slowly progressive paraparesis and T 2 hyperintensity in cord with flow voids in the spinal subarachnoid space must be investigated carefully with a spinal DSA. Filum terminale AVF's, if found can be easily treated with simple surgical disconnection that has gratifying results with clinical and radiological improvement seen in a short time.
| References|| |
|1.||Jellema K, Tijssen CC, van Gijn J. Spinal dural arteriovenous fistulas: A congestive myelopathy that initially mimics a peripheral nerve disorder. Brain 2006;129:3150-64. |
|2.||Shin MJ, Kim W, Baik SK, Kim SY, Kim SN. Cauda equina syndrome caused by spinal dural arteriovenous fistula. Ann Rehabil Med 2011;35:928-33. |
|3.||Kumar A, Deopujari CE, Mhatre M. Misdiagnosis in a case of non-compressive myelopathy due to a lumbar spinal intradural fistula supplied by the Artery of Adamkiewicz. Surg Neurol Int 2011;2:12. |
|4.||Spetzler RF, Detwiler PW, Riina HA, Porter RW. Modified classification of spinal cord vascular lesions. J Neurosurg 2002;96:145-56. |
|5.||Lim SM, Choi IS, David CA. Spinal arteriovenous fistulas of the filum terminale. AJNR Am J Neuroradiol 2011;32:1846-50. |
|6.||Trinh VT, Duckworth EA. Surgical excision of filum terminale arteriovenous fistulae after lumbar fusion: Value of indocyanine green and theory on origins (a technical note and report of two cases). Surg Neurol Int 2011;2:63. |
|7.||Djindjian M, Ribeiro A, Ortega E, Gaston A, Poirier J. The normal vascularization of the intradural filum terminale in man. Surg Radiol Anat 1988;10:201-9. |
|8.||Meisel HJ, Lasjaunias P, Brock M. Modern management of spinal and spinal cord vascular lesions. Minim Invasive Neurosurg 1995;38:138-45. |
|9.||Witiw CD, Fallah A, Radovanovic I, Wallace MC. Sacral intradural arteriovenous fistula treated indirectly by transection of the filum terminale: Technical case report. Neurosurgery 2011;69:E780-4. |
|10.||Tender GC, Vortmeyer AO, Oldfield EH. Spinal intradural arteriovenous fistulas acquired in late adulthood: Absent spinal venous drainage in pathogenesis and pathophysiology. Report of two cases. J Neurosurg Spine 2005;3:488-94. |
[Figure 1], [Figure 2], [Figure 3], [Figure 4]
[Table 1], [Table 2], [Table 3]
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|[Pubmed] | [DOI]|