| CASE REPORT |
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| Year : 2014 | Volume
: 17
| Issue : 2 | Page : 227-230 |
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Primary diffuse leptomeningeal gliomatosis: An autopsy case report
Shaik Afshan Jabeen1, Arikapadu Haritha Chowdary1, Rukmini Mridula Kandadai1, Megha S. Uppin2, Angamattu Kanikannan Meena1, Rupam Borgohain1, Challa Sundaram2
1 Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
2 Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India
Correspondence Address:
Shaik Afshan Jabeen
Department of Neurology, Nizam's Institute of Medical Sciences, Punagutta, Hyderabad
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-2327.132647
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Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare condition, characterized by infiltration of the meninges by glial cells without evidence of the primary tumor in the brain or spinal cord parenchyma. Glioma arising primarily from the leptomeninges is extremely rare and often diagnosed only in post mortem examination and the diagnosis may be missed in meningeal biopsy. We describe a young female who presented with symptoms of raised intracranial pressure with imaging evidence of diffuse leptomeningeal enhancement in whom autopsy confirmed the diagnosis of PDLG. Our case illustrates the diagnostic difficulties in making the pre-mortem diagnosis even with multiple cerebrospinal fluid cytologies and leptomeningeal biopsy. |
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