|
 |
|
ORIGINAL ARTICLE |
|
|
|
| Year : 2015 | Volume
: 18
| Issue : 2 | Page : 215-218 |
| |
Guillain-Barré syndrome complicating pregnancy and correlation with maternal and fetal outcome in North Eastern India: A retrospective study
Shri Ram Sharma, Nalini Sharma, Hussain Masaraf, Santa A Singh
Department of Neurology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India
| Date of Submission | 24-Sep-2014 |
| Date of Decision | 14-Sep-2014 |
| Date of Acceptance | 07-Oct-2014 |
| Date of Web Publication | 8-May-2015 |
Correspondence Address:
Shri Ram Sharma
Department of Neurology, North Eastern Indira Gandhi Regional Institute of Medical Sciences, Shillong - 793 018, Meghalaya
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-2327.150608
 Abstract | | |
Background: Guillain-Barré syndrome (GBS) is rare in pregnancy with an estimated incidence between 1.2 and 1.9 cases per 100,000 people annually, and it is generally accepted that it carries a high maternal risk. Most reports of GBS with pregnancy are case reports only. Aim: Purpose of this retrospective study was to find the correlation between pregnancy and GBS. Settings and Design: Records of patients admitted in neurology division were analyzed in a tertiary care teaching hospital in the northeastern Indian pregnant female population with GBS between 15-49 years during the period of 2009-2013. Materials and Methods: We analyzed the records of 47 patients with pregnancy and GBS, evaluated and treated in our institute from August 2009 to December 2013. This is retrospective observational study done in North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), India. Result: Predominant form of GBS was acute inflammatory demyelinating polyneuropathy (AIDP). The weakness started from the lower limbs in majority of patients. Ten percent of women had bifacial weakness. Most of patients had good maternal and fetal outcome. Two patients received intravenous immunoglobulin (IVIG). Only two patient required ventilator supports and one patient had intrauterine death (IUD) and died due to respiratory failure. Conclusion: Our results indicate that risk of GBS increases in third trimester and first 2 weeks after delivery. Demyelinating variety of GBS was common in our population. GBS natural course during pregnancy is mild and showed quick recovery. Maternal and perinatal outcome was good.
Keywords: Guillain-Barré syndrome, immunoglobulins, post-partum period, pregnancy
How to cite this article:
Sharma SR, Sharma N, Masaraf H, Singh SA. Guillain-Barré syndrome complicating pregnancy and correlation with maternal and fetal outcome in North Eastern India: A retrospective study. Ann Indian Acad Neurol 2015;18:215-8 |
How to cite this URL:
Sharma SR, Sharma N, Masaraf H, Singh SA. Guillain-Barré syndrome complicating pregnancy and correlation with maternal and fetal outcome in North Eastern India: A retrospective study. Ann Indian Acad Neurol [serial online] 2015 [cited 2022 Oct 6];18:215-8. Available from: https://www.annalsofian.org/text.asp?2015/18/2/215/150608 |
| Introduction | |  |
Guillain Barre Syndrome (GBS) is an acute monophonic type of inflammatory demyelinating polyradiculoneuropathy usually associated with symmetrical progressive muscle weakness, areflexia (loss of tendon jerks), and albumin cytological dissociation (a raised protein level but normal cell count) in the cerebrospinal fluid. The diagnostic criteria for GBS are well - defined. [1] Some case reports indicate that GBS occurrence during pregnancy may have been lower than expected. [2] GBS can occur in any trimester of pregnancy and post-partum period but particularly in third trimester and first 2 weeks post-partum. GBS is known to worsen in post partum period due to an increase in delayed type of hypersensitivity. The neglect regarding study of GBS complicating pregnancy may have resulted from one of many gaps in our arbitrary medical division of labor (no pun intended). Other investigators having taken the position that pregnancy is someone else's business, the more remote consequences of pregnancy and the puerperium have been left for the obstetricians, who are kept busy enough with short term outcomes. [2] Delayed diagnosis is common in pregnancy or immediate postpartum period because the initial non-specific symptoms may mimic changes in the pregnancy. [3] The relation between GBS and pregnancy or delivery is of special interest because of the dramatic character of GBS symptoms in a woman facing delivery. The purpose of this study was to quantity the risk of GBS for the mother during the pregnancy and postpartum periods and look for correlation between pregnancy and GBS. It has never been reported to the best of author's knowledge and belief.
| Materials and Methods | | |
We did a retrospective descriptional analysis of all females cases of >16 years women of GBS with pregnancy that were admitted in the hospital between August 2009 to December 2013. Records of the medical records departments were searched. Confirmed cases of GBS with pregnancy were selected based on standard clinical criteria. [4] A total of 47 patients were admitted with diagnosis of GBS with pregnancy were studied. Epidemiological data was collected including duration of symptoms before admission and duration of hospital stay. The pattern of involvement of limbs was recorded. GBS disability scaled adapted from Hughes et al. [5] Involvements of cranial nerves were looked for in all patients. Cerebrospinal fluid (CSF) study done in all cases. Nerve Conduction study was performed within 2 weeks of illness and if indicated was repeated using conventional procedures. Patients were classied acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN) or others on the basis of electro diagnostic criteria reported by Hadden and colleagues. [6] Patients were GBS with pregnancy without any of above three were excluded from the study even if recovered GBS were noted. All obstetrics parameters were studied in detail including fetal outcome.
| Results | | |
Forty-seven patients fulfilled the criteria for study. The median age of patients were 25.6 yrs (range 16-49) [Table 1]. The mean duration of symptoms on admission was 5.17 days (range 2-19 days). The mean duration of hospital stay was 7.3 days (range 4-25 days). All patients presented at stage 1, that is progressive phase [Table 2]. Sensory symptoms were present in 32 (68%) whereas only two patients had sensory findings on examination. No patients had extraocular muscle involvement. Only five (10%) had bifacial weakness. Oropharyngeal weakness was observed in seven (14.8%). GBS disability scale adapted from Hughes et al., ranged from grade 4-5 (more than 3). One patient presented in first trimester, seven patients (14.89%) were in second trimester, 15 (31.2%) were in third trimester and remaining 24 (51%) were presented in postpartum especially within 2 weeks. Electrophysiological subtypes - based on electrophysiological criteria, 32 (72.7%) of 44 patients were classified as AIDP and 12 (27.2%) of 44 patients as AMAN. Electrophysiological data were not available in three patients. Dysautonomia was seen in nine (19.1%). Twenty three (48.9%) had onset of weakness in the lower limbs and rest had simultaneous weakness in both upper and lower limbs. CSF analysis of all patients showed albuminocytological dissociation universally. Two patients received intravenous immunoglobulin (IVIG) infusions as our institute have no facilities for plasmapheresis.
Vital Capacity less than 20 mL/kg or a decline by 30% from baseline, maximal inspiratory pressure less than 30 cm H 2 0, and maximal expiratory pressure of less than 40 cm H 2 0 was highly correlated with a subsequent progression to respiratory failure and intubation. The use of these data ("20/30/40 rule") allowed identification of patients at risk of respiratory failure early and the institution of preemptive measures such as admission to the ICU. Elective intubation for ventilator assistance was performed when FVC fallen below 12-15 ml/kg or below 18 ml/kg in patients with severe oropharyngeal weakness, or when arterial P O2 values fall below 70 mm Hg with inspired room temperature. Two patients developed respiratory distress and required mechanical ventilation. Two patients undergone cesarean section as one was having history of previous two cesarean deliveries and one had transverse lie presentation rest two were operated outside, admitted as postpartum GBS. One patient had instrumental (ventuse) delivery [Table 3]. Half of (50%) postpartum were delivered at home. Two patients who had stillbirth one was delivered at home. Apgar score was >7 in most of delivered babies [Table 4]. Only one woman had intrauterine death and died due to respiratory failure. Patients were followed-up for 6 months for recurrence, disability. Overall outcome was good irrespective of electrophysiological subtypes.
| Discussion | | |
GBS represent a heterogeneous group of immune mediated peripheral neuropathy. The preceding infection may cause an autoimmune response against the various components of peripheral nerve myelin and sometimes the axon. [5] GBS classically presents with pain, numbness, paresthesia, or weakness of the limbs and this can be mistaken for a psychological complaint, leading to delay in diagnosis and treatment. [7] Although the etiology of GBS is unknown, there is strong evidence that autoimmune mechanisms play a major role in GBS pathogeneses.
Reports from nonpregnant population revealed that antecedent infectious event could be identified in two-thirds of cases. In our study we did not perform serological tests for Capylobacter jejuni, CMV, EBV and Mycoplasma pneumoniae due to financial constrains.
GBS can occur in any trimester of pregnancy and post-partum period but particularly in third trimester and first 2 weeks post-partum. [8] In our study this observation was confirmed. GBS is known to worsen in post partum period as most of our study (51%) population was, due to an increase in delayed type of hypersensitivity as reported by da Silva et al., when GBS was diagnosed at 15 weeks of pregnancy and aggravated post partum. [9]
Up to 20% of patients are disabled after 1 year and a maternal mortality of exceeding 10% has been described (nonpregnant GBS has mortality <5%). [10] Reports before the mid-1980 suggested that GBS in pregnancy carries a high maternal morbidity and mortality. [11] It was reported that as many as 34.5% of women suffering from GBS during pregnancy required ventilator support. [12] Our observation contradict earlier study as majority of our patient recovered well and needed no mechanical support. This can be explained by majority of studied women had demyelinating variety of GBS and it is uncertain whether availability of active treatment such as plasmapheresis and immunoglobulin together with advancement in intensive care has improved maternal outcome.
It was of opinion that management of pregnancy with GBS does not differ much from that in nonpregnant patients with this disease. Two patients received IVIG infusion Supportive care remained cornerstone of treatment in most of our patients. Management of airway and respiratory infection, maintaining fluid and electrolyte balance, nutritional support and effective rehabilitation was taken care. Attention was paid to the identification and treatment of infective complications such as nosocomial infection and urinary tract infection because of common occurrence and more severe in pregnant women, prevention of venous thromboembolism, pain and dysesthesias management and the management of psychological distress resulting from disease and anxiety towards pregnancy. Apart from that physiotherapy and early mobilization was encouraged.
Most of our patients delivered normally except two patients who undergone cesarean section had obstetric indications. Therefore abortion or cesarean sections are not considered to be indicated. [11] Ventuse was applied to one patient to reduce prolonged second stage of labor. So unnecessary obstetric intervention must be strongly resisted. [13]
Bahadur et al., described a 25-year-old gravid 3, para2, woman at 21 weeks of pregnancy with successful maternal and fetal outcome. [14] Majority of our women were multiparous as in Meghalaya grand multiparity is very common and it did not affect outcome. The fact that the incidence of GBS during the first 4 months of pregnancy was not low, comprising one admitted in our study patient, argues against the notion of a protective effects of the first months of pregnancy. Vijayraghavan et al., have reported its management at 16 weeks of pregnancy. [7] Goyal et al., have reported the management of a primigravida presenting at 26 weeks of gestation with plasmapheresis. [15]
Risk of prematurity is low and occasionally fetal death may occur as in one of our pregnant patient who died along with stillbirth. In case ventilator support is required in pregnancy, the risk of premature birth has been noted to be greatly increased. [14] Hence an obstetrician must be vigilant if a pregnant woman complains of generalized muscular weakness and respiratory discomfort.
Exposure to certain known risk factors of GBS, such as certain infections or drugs, precedes GBS onset by about 2 weeks. [16] Thus the increased risk maybe caused by some unidentified factors acting near the end of pregnancy. Because humoral factors are shared by mothers and their neonates via passive transfer whereas cellular components are not, the hypothesis that cell mediated immunity is the major mechanism in the pathogenesis of GBS is highly plausible. [16] One mechanism that has been proposed is that of endogenous antigen transfer. Fetal cells do move into the maternal circulation. [17],[18] The endogenous antigen transfer to a system temporarily disarmed with respect to the recognition of nonself could play a role.
Changes in the physiology of the immune system offer a more likely alternative. It is thought that pregnancy temporarily enhances the production of anti-inflammatory Th2 cytokines which are secreted at the maternal-fetal interface and act systemically. [19] These agents promote humoral immunity, downgrade production of proinflammatory Th1 cytokines, which are deleterious to pregnancy in women, and thereby facilitate growth and development of the "fetal allograft". Proinflammatory cytokines clearly plays a role in the pathogenesis of chronic autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. [20]
To the extent that this GBS with pregnancy is considered representative of pathogenesis of other autoimmune conditions, our findings should stimulate interest among obstetricians as well as neurologists.
| Conclusion | | |
GBS course during pregnancy is mild and showed quick recovery. Our results indicate that risk of GBS increases in third trimester and first 2 weeks after delivery. It can be concluded that demyelinating variety of GBS is common in our study population. It highlights the combined role of gynecologist and neurologists in the management of GBS during pregnancy, which if missed can be detrimental, both for mother and fetus. Early diagnosis and prompt intensive multidisciplinary supportive care in GBS complicating pregnancy improves the prognosis for both mother and fetus.
| References | | |
| 1. | Asbury AK. Guillain Barre syndrome: Historic aspect. Ann Neurol 1990;27:S2-6.  |
| 2. | Mack T, Weiner L, Gilmore W. Guillain Barre syndrome, pregnancy and the puerperium. Epidemiology 1998;9:588-90. [ PUBMED] |
| 3. | Zafar MS, Naqash MM, Bhat TA, Malik GM. Guillain Barre syndrome in pregnancy: An unusal case. J Family Med Prim Care 2013;2:90-1. |
| 4. | Asbury AK, Cornblath DR. Assessment of current diagnostic criteria for Guillain Barre syndrome. Ann Neurol 1990;27:S21-4. |
| 5. | Hughes RA, Cornblath DR. Guillain Barre syndrome. Lancet 2005;366:1653-66. |
| 6. | Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, et al. Electrophysiological classification of Guillain Barre syndrome: Clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group. Ann Neurol 1998;44:780-8. |
| 7. | Vijayaraghavan J, Vasudevan D, Sadique N, Rajeshwari KS, Pondurangi M, Jayashree. A rare case of Guillain Barre syndrome with pregnancy. J Indian Med Assoc 2006;104:269-70. |
| 8. | Zeeman GG. A case of acute inflammatory demyelinating polyradiculoneuropathy in early pregnancy. Am J Perinatol 2001;18:213-5. |
| 9. | Campos da Silva Fde Mores Paula G, Dos Santos Esteves Automari CV, Mendes de Almeida DS, Ubirajara Cavalcanti Guimaraes R. Guillain Barre syndrome in pregnancy: Ealy diagnosis and treatment is essential for a favorable outcome. Gynecol Obstet Invest 2009;67:236-7. |
| 10. | Furara S, Maw M, Khan F, Powell K. Weakness in pregnancy - Expect the unexpected. Obstet Med 2008;1:99-101. |
| 11. | Chan LY, Tsui MH, Leung TN. Guillain Barre syndrome in pregnancy. Acta Obstet Gynecol Scand 2004;83:319-25. |
| 12. | Nelson LH, Melean WT Jr. Management of Landry-Guillain Barre syndrome in pregnancy. Obstet Gyecol 1985;65:25-9S. |
| 13. | Inamdar SA, Inamdar AH, Chaudhary R, Subhedar VS. Successful maternal and fetal outcome of Guillain-Barré syndrome complicating pregnancy. Int J Repro Contracep Obstet Gynecol 2013;2:478-9. |
| 14. | Bahadur A, Gupta N, Deka D, Mittal S. Successful maternal and fetal outcome of Guillain-Barré syndrome complicating pregnancy. Indian J Med Sci 2009;63:517-8. [ PUBMED]  |
| 15. | Goyal V, Misra BK, Singh S, Prasad K, Behari M. Acute inflammatory demyelinating poly neuropathy in patients with pregnancy. Neurol India 2004;52:283-4. [ PUBMED] |
| 16. | Winer JB, Hughes RA, Anderson MJ, Jones DM, Kangro H, Warkins RP. A prospective study of acute idiopathic neuropathy. II. Antecedent events. J Neurol Neurosurg Psychiatry 1988;51:613-8. |
| 17. | Rolf A, Bolik A. Guillain Barre syndrome in pregnancy: Reflection on immunopathogenesis. Acta Neurol Scand 1994;89:400-2. |
| 18. | Nelson JL, Ostensen M. Pregnancy and rheumatoid arthritis. Rheum Dis Clin North Am 1997;23:195-212. |
| 19. | Raghupathy R. Th1-type is immunity is incompatible with successful pregnancy. Immunol Today 1997;18:478-82. |
| 20. | Feldmann M, Brennan FM, Maini RN. Rheumatoid arthritis. Cell 1996;85:307-10. |
[Table 1], [Table 2], [Table 3], [Table 4]
| This article has been cited by | | 1 |
Outcome of Guillain-Barré Syndrome (GBS) during peripartum period: A hospital-based observational study |
|
| AnilKumar Patra, Marami Das, SaswatiSanyal Choudhury, Munindra Goswami, K Vanlalzami | | Annals of Indian Academy of Neurology. 2022; 25(3): 417 | | [Pubmed] | [DOI] | | | 2 |
Risk factors of impulsive-compulsive behaviors in PD patients: a meta-analysis |
|
| Lanxiao Cao, Tian Xu, Gaohua Zhao, Dayao Lv, Jinyu Lu, Guohua Zhao | | Journal of Neurology. 2021; | | [Pubmed] | [DOI] | | | 3 |
Guillain Barre Syndrome following delivery in a pregnant woman infected with SARS-CoV-2 |
|
| Arzu Bilge Tekin, Umit Zanapalioglu, Selcen Gulmez, Ilkyaz Akarsu, Murat Yassa, Niyazi Tug | | Journal of Clinical Neuroscience. 2021; 86: 190 | | [Pubmed] | [DOI] | | | 4 |
Guillain–Barré
syndrome during pregnancy: A case series
|
|
| Mirjana Ždraljevic, Vanja Radišic, Stojan Peric, Aleksandra Kacar, Dejana Jovanovic, Ivana Berisavac | | Journal of Obstetrics and Gynaecology Research. 2021; | | [Pubmed] | [DOI] | | | 5 |
Intravenous immunoglobulin in COVID-19 associated Guillain–Barré syndrome in pregnancy |
|
| Jao Jarro Garcia, Christian Wilson Turalde, Marjorie Anne Bagnas, Veeda Michelle Anlacan | | BMJ Case Reports. 2021; 14(5): e242365 | | [Pubmed] | [DOI] | | | 6 |
Guillain Barre Syndrome in Pregnancy - A Rare Case |
|
| Madhuri Patil, Trupti Wankhede | | Journal of Evidence Based Medicine and Healthcare. 2021; 8(33): 3172 | | [Pubmed] | [DOI] | | | 7 |
Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development |
|
| Niel A. Karrow, Umesh K. Shandilya, Steven Pelech, Lauraine Wagter-Lesperance, Deanna McLeod, Byram Bridle, Bonnie A. Mallard | | Vaccines. 2021; 9(11): 1351 | | [Pubmed] | [DOI] | | | 8 |
Validation of the Korean Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Rating Scale |
|
| Ji-Hyun Choi, Jee-Young Lee, Jin Whan Cho, Seong-Beom Ko, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Joong-Seok Kim, Yoon-Joong Kim, Hyeo-Il Ma, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, In-Uk Song, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeok Lee, Ji-Young Kim, Ji Sun Kim, Ji Young Yun, Hee Jin Kim, Jin Yong Hong, Mi-Jung Kim, Jinyoung Youn, Ji Seon Kim, Eung Seok Oh, Hui-Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum-Yil Kwon, Hyung-Eun Park, Su-Yun Lee, Younsoo Kim, Hee-Tae Kim, Mee Young Park | | Journal of Clinical Neurology. 2020; 16(2): 245 | | [Pubmed] | [DOI] | | | 9 |
Trauma-Related Guillain–Barré Syndrome: Systematic Review of an Emerging Concept |
|
| Chuxin Huang, Yiliu Zhang, Shuwen Deng, Yijun Ren, Wei Lu | | Frontiers in Neurology. 2020; 11 | | [Pubmed] | [DOI] | | | 10 |
Dynamics of impulsive–compulsive behaviors in early Parkinson’s disease: a prospective study |
|
| Vladana Markovic, Iva Stankovic, Igor Petrovic, Tanja Stojkovic, Nataša Dragaševic-Miškovic, Saša Radovanovic, Marina Svetel, Elka Stefanova, Vladimir Kostic | | Journal of Neurology. 2020; 267(4): 1127 | | [Pubmed] | [DOI] | | | 11 |
Guillain–Barre syndrome in pregnancy and its association with maternal and perinatal outcome |
|
| V Rupalakshmi, ShraddhaK Shetty | | Muller Journal of Medical Sciences and Research. 2019; 10(2): 58 | | [Pubmed] | [DOI] | | | 12 |
Clinical Reasoning: Acute onset of diplopia in pregnancy |
|
| Zea Munro, Desiree Fernandez | | Neurology. 2018; 91(2): e180 | | [Pubmed] | [DOI] | |
|
|
|
|
|
|
|
|
