| CASE REPORT |
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| Year : 2015 | Volume
: 18
| Issue : 3 | Page : 345-347 |
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Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A case report and review of literature
Soma Madhan Reddy1, Rahul Lath1, Meenakshi Swain2, Alok Ranjan1
1 Department of Neurosurgery, Apollo Health City, Jubilee Hills, Hyderabad, Andhra Pradesh, India
2 Department of Pathology, Apollo Health City, Jubilee Hills, Hyderabad, Andhra Pradesh, India
Correspondence Address:
Rahul Lath
Department of Neurosurgery, Apollo Health City, Jubilee Hills, Hyderabad - 500 033, Andhra Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-2327.152085
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Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of central nervous system with distinct clinical and radiological features. The etiopathogenesis of this rare entity remains to be understood. The histopathological findings closely resemble chronic inflammatory diseases like sarcoidosis and malignancies like lymphoma. With advancements in serology, immunopathology and radiology CLIPPERS is identified as a distinct entity that differs considerably in its clinical presentation, immunopathology, radiological findings and response to steroids. We describe a case that presented to us with progressive quadriparesis and lower cranial nerve deficits whose radiological and pathological findings were consistent with CLIPPERS. The patient had a good outcome with long term immunosuppression. |
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