Annals of Indian Academy of Neurology
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Year : 2016  |  Volume : 19  |  Issue : 1  |  Page : 79-82

Intravenous levetiracetam in critically ill children

1 Department of Pediatric Neurology, Cukurova University, Adana, Turkey
2 Department of Pediatric Intensive Care Unit, Cukurova University, Adana, Turkey

Correspondence Address:
Faruk Incecik
Toros Mah, Barış Manço Bul. 78178 Sok., Yeşilpark Evleri, A Blok, Kat: 7/13, Çukurova, Adana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-2327.167702

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Background: To report the effectiveness and safety of intravenous (IV) levetiracetam (LEV) in the treatment of critically ill children with acute repetitive seizures and status epilepticus (SE) in a children's hospital. Materials and Methods: We retrospectively analyzed data from children treated with IV LEV. Results: The mean age of the 108 children was 69.39 ± 46.14 months (1-192 months). There were 58 (53.1%) males and 50 (46.8%) females. LEV load dose was 28.33 ± 4.60 mg/kg/dose (10-40 mg/kg). Out of these 108 patients, LEV terminated seizures in 79 (73.1%). No serious adverse effects were observed but agitation and aggression were developed in two patients, and mild erythematous rash and urticaria developed in one patient. Conclusion: Antiepileptic treatment of critically ill children with IV LEV seems to be effective and safe. Further study is needed to elucidate the role of IV LEV in critically ill children.

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