Annals of Indian Academy of Neurology
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Year : 2020  |  Volume : 23  |  Issue : 3  |  Page : 318-324

COVID-19 and \ stroke: Incidental, triggered or causative

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Rohit Bhatia
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi - 110029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aian.AIAN_380_20

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Stroke is a serious neurological complication observed during the ongoing COVID-19 (coronavirus associated disease 2019) pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome, corona virus 2) and includes both ischemic stroke and intracerebral haemorrhage. We reviewed factors that could potentially contribute to the occurrence of stroke among patients with COVID-19. There could be an interaction between the conventional risk factors of stroke, infection, systemic inflammatory response and plaque destabilisation. Inflammatory markers, D-dimer elevation and increased cytokine activity have all been observed in patients with COVID-19. Other probable contributing factors include cardiac injury leading to embolism, a prothrombotic state and a possibility of direct neuroinvasive potential causing vasculopathy. Data from stroke patients gathered in large multicentric cohorts could help shed more light on the occurrence, behaviour, aetiology, pathophysiology, biomarkers and outcomes of stroke occurring during the ongoing pandemic.

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