Annals of Indian Academy of Neurology
: 2015  |  Volume : 18  |  Issue : 4  |  Page : 478-

Dot sign and dengue encephalitis

Sora Yasri1, Viroj Wiwanitkit2,  
1 KMT Primary Care Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, China; Visiting Professor, Faculty of Medicine, University of Nis, Serbia; Adjunct Professor, Joseph Ayobabalola University, Nigeria; Honorary Professor, Dr. DY Patil Medical University, Pune, Maharashtra, India

Correspondence Address:
Sora Yasri
KMT Primary Care Center, Bangkok Thailand

How to cite this article:
Yasri S, Wiwanitkit V. Dot sign and dengue encephalitis.Ann Indian Acad Neurol 2015;18:478-478

How to cite this URL:
Yasri S, Wiwanitkit V. Dot sign and dengue encephalitis. Ann Indian Acad Neurol [serial online] 2015 [cited 2022 Oct 3 ];18:478-478
Available from:

Full Text


The recent report on "Dot sign and dengue encephalitis" is very interesting. [1] The finding of dot sign in diagnosis of dengue encephalitis should be commented. In this case, "transient splenial hyperintensityappearing asdot sign in magnetic resonance imaging (MRI)" is mentioned. [1] Indeed, "dot sign" is classically mentioned in some diseases, but not infectious disease as dengue. [2] Transient splenial hyperintensitycan be seen in many neurological problems such as cryptococcal meningitis [3] and epilepsy. [4] The concomitant disorder in the present case is questionable. Indeed, dengue encephalitis is an uncommon neurological presentation of dengue and the clinical features can hardly be differentiated from other encephalitis. [5] The MRI seems to be not helpful for definitive and differential diagnosis. [5]


1Mathew T, Badachi S, Raja G, Nadig R. "Dot sign" in dengue encephalitis. Ann Indian Acad Neurol 2015;18:77-9.
2Ventureyra EC, Abdel Aziz H. The "dot sign". Pediatr Neurosurg 2001;35:111.
3Thomas B, Kesavadas C. Neurological picture. Focal splenial hyperintensity in epilepsy. J Neurol Neurosurg Psychiatry 2006;77:202.
4Sen K, Guha G, Khandelwal K, Lalhmachhuana J. The enigma of transient splenial hyperintensity: In cryptococcal meningitis. J Neurosci Rural Pract 2013;4:352-5.
5Verma R, Sahu R, Holla V. Neurological manifestations of dengue infection: A review. J Neurol Sci 2014;346:26-34.