Annals of Indian Academy of Neurology
ORIGINAL ARTICLE
Year
: 2018  |  Volume : 21  |  Issue : 3  |  Page : 214--219

Predictors of intracerebral hemorrhage in acute stroke patients receiving intravenous recombinant tissue plasminogen activator


Vijay Chenna, Subhash Kaul, Swetha Tandra, Sireesha Yareeda, Neeharika Mathukumalli, Abhijeet Kumar Kohat, Rukmini Mridula Kandadai, Suryaprabha Turaga, Jabeen Afshan Sheik, AK Meena, Rupam Borgohain 
 Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India

Correspondence Address:
Dr. Subhash Kaul
Department of Neurology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, Telangana
India

Background: Symptomatic Intracerebral hemorrhage (sICH) is a serious complication of recombinant tissue-plasminogen activator (rt-PA) therapy for acute ischemic stroke (AIS). Objective: To estimate the prevalence and predictors of sICH in patients after receiving IV rt-PA for AIS. Material and Methods: Consecutive patients of AIS thrombolysed between January 2010 and June 2016 in a University hospital in Hyderabad (India) were studied prospectively for sICH and it's various variables compared with the control group without sICH to determine any sigificantant difference. Results: Out of 113 patients , sICH was detected in 12 (10.61%) whose mean age(58±12.0 years) and gender ratio ( 2:1 ) was not statistically significant from controls. In s ICH group mean NIHSS score was 16.53± 5.81 vs 10.19± 5.06 in controls (p<0.001), gap between stroke onset and thrombolysis was 227.50±46.15 min vs 178.50± 69.20 min in controls(p=0.018).At presentation mean blood sugar was 208.75±90.97 mg/dl in sICH group vs 146.83±70.21 mg/dl in controls (p=0.002). Prior diabetes was in 7(53.30%) vs 23 (22.8%) in controls (p= 0.014)and hypertension in 11 (91.7%) vs (56(55.4%) in controls (p= 0.026) The mortality in sICH was 7 (58.30%)vs 4 (4.94%) in controls (p<.0.001). At 3 months mean mRS ofsICH patients was 5.57± 0.54 vs 2.17± 1.69 in controls (p<.05). Conclusion: High NIHSS score, increased stroke onset to thrombolysis time , high blood sugar at presentation ,prior diabetes and hypertension increase the chances of sICH. None of these contraindicate thrombolysing strokes but should caution the physician.


How to cite this article:
Chenna V, Kaul S, Tandra S, Yareeda S, Mathukumalli N, Kohat AK, Kandadai RM, Turaga S, Sheik JA, Meena A K, Borgohain R. Predictors of intracerebral hemorrhage in acute stroke patients receiving intravenous recombinant tissue plasminogen activator.Ann Indian Acad Neurol 2018;21:214-219


How to cite this URL:
Chenna V, Kaul S, Tandra S, Yareeda S, Mathukumalli N, Kohat AK, Kandadai RM, Turaga S, Sheik JA, Meena A K, Borgohain R. Predictors of intracerebral hemorrhage in acute stroke patients receiving intravenous recombinant tissue plasminogen activator. Ann Indian Acad Neurol [serial online] 2018 [cited 2021 Mar 1 ];21:214-219
Available from: https://www.annalsofian.org/article.asp?issn=0972-2327;year=2018;volume=21;issue=3;spage=214;epage=219;aulast=Chenna;type=0